16 Papers
76 Citations
Xiaojie Wu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 8 publications.
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Papers
Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice.
Hongxu Wu,Shifang Yang,Xiaojie Wu,Junling Zhao,Jianping Zhao,Qin Ning,Yongjian Xu,Jungang Xie +7 more
TL;DR: It is found that IL-33 could induce and enhance the expression of IL-6 and IL-8 in PBMCs of COPD mice via p38 MAPK pathway, and it is a promoter of the IL- 6 and IL -8 production in systemic inflammation in COPd mice.
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Interleukin-33 promotes inflammatory cytokine production in chronic airway inflammation.
TL;DR: IL-33 is a promoter of chronic airway inflammation that contributes to COPD development and could induce and enhance the expression of IL-6 and IL-8 in HBE cells and PBMCs of COPD patients via ST2/IL-1RacP pathway and MAPKs pathway.
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Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease
Yuan Zhan,Jinkun Chen,Jixing Wu,Yiya Gu,Qian Huang,Z. Deng,Shanshan Chen,Xiaojie Wu,Yongman Lv,Zhilin Zeng,Jungang Xie +10 more
TL;DR: In this article , the role of HE4 in COPD was investigated using immunohistochemical staining, qPCR, western blot, CCK8 assay or 5-ethynyl-2'-deoxyuridine (EdU) staining.
Genotoxicity and reduced heat shock protein 70 in human airway smooth muscle cells exposed to cigarette smoke extract
TL;DR: It was concluded that cigarette smoke induced genotoxicity and decreased the production of cell protective protein Hsp70, which may contribute to the development of some airway diseases.
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Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes
TL;DR: Lower plasma CC10 was associated with enhanced airway hyperresponsiveness, and Type 2 inflammation, and Plasma CC10 is potentially useful in predicting T2-high and T1-low asthma.
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