Xiaojie Chen
Zhejiang Chinese Medical University
9 Papers
4 Citations
Xiaojie Chen is an academic researcher from Zhejiang Chinese Medical University. The author has contributed to research in topics: Photothermal therapy & Chemistry. The author has an hindex of 4, co-authored 7 publications.
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Papers
Targeted Manganese doped silica nano GSH-cleaner for treatment of Liver Cancer by destroying the intracellular redox homeostasis.
Hongxia Tang,Chaoqun Li,Yue Zhang,Hongyue Zheng,Ying Cheng,Jingjing Zhu,Xiaojie Chen,Zhihong Zhu,Ji-Gang Piao,Fanzhu Li +9 more
TL;DR: Target sorafenib loaded manganese doped silica nanoparticle (FaPEG-MnMSN@SFB) was constructed, which could destroy the intracellular redox homeostasis by consuming GSH and cause multi-path programmed cell death and could be a promising strategy for cancer therapy.
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Photothermal/matrix metalloproteinase-2 dual-responsive gelatin nanoparticles for breast cancer treatment.
Xiaojie Chen,Jiafeng Zou,Ke Zhang,Jingjing Zhu,Yue Zhang,Zhihong Zhu,Hongyue Zheng,Fanzhu Li,Ji-Gang Piao +8 more
TL;DR: GNP-DOX/ICG could efficiently suppress the growth of 4T1 tumor in vivo and may provide a promising strategy in the rational design of drug delivery nanosystems based on gelatin for chemo-photothermal therapy to achieve synergistically enhanced therapeutic efficacy against breast cancer.
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Angiopep-2 modified lipid-coated mesoporous silica nanoparticles for glioma targeting therapy overcoming BBB.
Jingjing Zhu,Ying Zhang,Xiaojie Chen,Yue Zhang,Ke Zhang,Hongyue Zheng,Yinghui Wei,Hangsheng Zheng,Jiazhen Zhu,Fang Wu,Ji-Gang Piao,Zhihong Zhu,Fanzhu Li +12 more
TL;DR: The therapy of intracranial C6 glioma bearing rats was increasingly efficient, and angiopep-2 modified lipid-coated mesoporous silica nanoparticle loading paclitaxel (ANG-LP-MSN-PTX) could prolong the survival time of model rats, suggesting it might hold great promise as a targeting delivery system forglioma treatment.
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Microwave-triggered/HSP-targeted Gold Nano-system for Triple-negative Breast Cancer Photothermal Therapy
TL;DR: In vitro and in vivo results indicated that the induction through microwave irradiation could effectively activate the HSP70 overexpression in TNBC, thereby significantly improving the targeting ability, tumor accumulation and anti-tumor efficacy of cmHSP-AuNC.
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Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells.
Bing-bing Zhang,Xiaojie Chen,Xudong Fan,Jingjing Zhu,Yinghui Wei,Hangsheng Zheng,Hongyue Zheng,Bin-hui Wang,Ji-Gang Piao,Fanzhu Li +9 more
TL;DR: In this article, mesoporous silica nanoparticles (MSNs) coated with polyacrylic acid (PAA), and pH-sensitive lipid (PSL) for synergistic delivery and dual-pH-responsive sequential release of arsenic trioxide (ATO) and paclitaxel (PTX) were developed.
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