Xiaohui Sem
Agency for Science, Technology and Research
5 Papers
Xiaohui Sem is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Biology & CD14. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Xiaohui Sem include Singapore Immunology Network.
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Papers
Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets.
Kok Loon Wong,June Jing Yi Tai,Wing-Cheong Wong,Hao Han,Xiaohui Sem,Wei Hseun Yeap,Philippe Kourilsky,Siew Cheng Wong +7 more
TL;DR: This work comprehensively defined the 3 circulating human monocyte subsets using microarray, flow cytometry, and cytokine production analysis, and finds that intermediate monocytes expressed a large majority (87%) of genes and surface proteins at levels between classical and nonclassical monocytes.
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Experimental evolution of a fungal pathogen into a gut symbiont
Gloria Hoi Wan Tso,Jose Antonio Reales-Calderon,Alrina Shin Min Tan,Xiaohui Sem,Giang Thi Thu Le,Tze Guan Tan,Ghee Chuan Lai,Kandhadayar G. Srinivasan,Marina Yurieva,Webber Liao,Michael Poidinger,Francesca Zolezzi,Giulia Rancati,Norman Pavelka +13 more
TL;DR: By adaptively evolving the opportunistic fungal pathogen Candida albicans in the mouse gastrointestinal tract, strains that not only had lost their main virulence program but also protected their new hosts against a variety of systemic infections.
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Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods.
Changqing Zhao,Huoming Zhang,Wing-Cheong Wong,Xiaohui Sem,Hao Han,Siew-Min Ong,Yann-Chong Tan,Wei-Hseun Yeap,Chee-Sian Gan,Kok-Quan Ng,Mickey Koh,Philippe Kourilsky,Siu Kwan Sze,Siew Cheng Wong +13 more
TL;DR: Novel functional differences between the monocyte subsets are uncovered from differences in gene expression at the protein and mRNA levels, which would provide new insights into the different roles of the two monocytes subsets in regulating innate and adaptive immune responses.
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β-glucan Exposure on the Fungal Cell Wall Tightly Correlates with Competitive Fitness of Candida Species in the Mouse Gastrointestinal Tract.
Xiaohui Sem,Giang Thi Thu Le,Alrina Shin Min Tan,Gloria Hoi Wan Tso,Marina Yurieva,Webber Liao,Josephine Lum,Kandhadayar G. Srinivasan,Michael Poidinger,Francesca Zolezzi,Norman Pavelka +10 more
TL;DR: Recognition of exposed β-glucan by Dectin-1 receptor appears to severely limit Candida GI fitness and hence represents a promising target to reduce fungal colonization in patients at risks of systemic candidiasis.
The CD14(+/low)CD16(+) monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14(+)CD16(-) subset.
Changqing Zhao,Yann-Chong Tan,Wong Wc,Xiaohui Sem,Huoming Zhang,Han H,Siew-Min Ong,Kok Loon Wong,Wei-Hseun Yeap,Siu Kwan Sze,Philippe Kourilsky,Siew Cheng Wong +11 more
TL;DR: This is the first report of a differential apoptotic propensity of human monocyte subsets, and gaining a better understanding of this process may help to provide a betterUnderstanding of the roles of these subsets during homeostasis and under pathological conditions, particularly in situations in which high levels of oxidants are present.