Xiaohui Liu
5 Papers
Xiaohui Liu is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 1, co-authored 3 publications.
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Papers
The relationship between the weight-adjusted-waist index and left ventricular hypertrophy in Chinese hypertension adults
Shuang Cai,Tianyu Zhu,Ying Ding,Bokai Cheng,Anhang Zhang,Qiligeer Bao,Jingyu Sun,Man-shi Li,Xiaohui Liu,Shuxia Wang +9 more
TL;DR: The WWI may be an independent determinant of LVH in Chinese hypertension adults and logistic regression analysis suggested that the WWI was independently correlated with LVH with adjustment of confounding factors, and increased across the quartile of WWI.
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His-Purkinje system pacing reduced tricuspid regurgitation in patients with persistent atrial fibrillation after left-sided valve surgery
TL;DR: In this article , the effect of HPSP on tricuspid regurgitation in patients with persistent atrial fibrillation after left-sided valve surgery was investigated.
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Effect of angiotensin receptor-neprilysin inhibitor on atrial electrical instability in atrial fibrillation
Tianyu Zhu,Wen-Chao Zhang,Quan Yang,Ning Wang,Yuwei Fu,Yan Li,Guanliang Cheng,Liang Wang,Xian Zhang,Hongying Yao,Xing-Lan Sun,Yu Lu Chen,Xiaohui Wu,Xue-Jiao Chen,Xiaohui Liu +14 more
TL;DR: In this paper , the effect of angiotensin receptor-neprilysin inhibitor (ARNI) on atrial electrical instability and structural remodeling in patients with atrial fibrillation was investigated.
Relationship between β1-AA and AT1-AA and Cardiac Function in Patients with Hypertension Complicated with Left Ventricular Diastolic Function Limitation
Liang Wang,Xuebai Lv,Yu-Ting Yuan,Ning Wang,Hong-Ying Yao,Wen-Chao Zhang,Peng-Fei Yin,Xiaohui Liu +7 more
TL;DR: Both β1-AA and AT1-AA could be used as early markers of LVDD in essential hypertension patients and both autoimmune antibodies had a certain predictive value, and the combined prediction value of the two was the highest.
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Pentraxin 3 promotes the expression of pro-inflammatory cytokines and the migration of macrophages in myocarditis
Tianyu Zhu,Ying Ding,Xiaohui Wu,Yan Li,Ning Wang,Quan Yang,Wenchao Zhang,Xuezhi Chen,Xiaohui Liu +8 more
Abstract: This study aims to investigate the expression of Pentraxin 3 (PTX3) and Nod-like receptor family pyrin domain-containing 3 (NLRP3) in myocarditis and to elucidate their roles and potential interplay in the pathogenesis of myocarditis. Immunofluorescence staining was performed on myocardial autopsy specimens from deceased patients with severe myocarditis or severe trauma. H9C2 cardiomyocytes were divided into five groups: Control, Lipopolysaccharide (LPS), LPS + PTX3 overexpression, LPS + small interfering RNA targeting PTX3 (si-PTX3), and LPS + PTX3 overexpression + si-NLRP3. The expression levels of PTX3 and NLRP3 at the RNA level were quantified using quantitative real-time polymerase chain reaction (qPCR), while protein expression was assessed via western blot. The concentrations of interleukin-1β (IL-1β) and IL-18 were determined by enzyme-linked immunosorbent assay (ELISA). Macrophages migration was evaluated using Transwell assays. Immunofluorescence staining revealed co-localization and increased expression of PTX3 and NLRP3 in the myocardium of patients with severe myocarditis. In vitro experiments demonstrated that PTX3 enhanced the expression of NLRP3, IL-1β, and IL-18 in LPS-stimulated cardiomyocytes. Furthermore, PTX3 was shown to promote macrophage migration by regulating NLRP3 expression, as assessed by Transwell assays. Our findings suggest that PTX3-mediated NLRP3 activation contributes to inflammatory responses and promotes macrophage migration in myocarditis. This study provides a foundation for future investigations into PTX3-targeted therapies for myocarditis.