3 Papers
Xiaohua Lu is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Mycobacterium tuberculosis & Biology. The author has an hindex of 2, co-authored 2 publications. Previous affiliations of Xiaohua Lu include Singapore Immunology Network.
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Papers
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis
Catherine Y. Cheng,Nuria Martinez Gutierrez,Mardiana Marzuki,Xiaohua Lu,Taylor W. Foreman,Bhairav Paleja,Bernett Lee,Akhila Balachander,Jinmiao Chen,Liana Tsenova,Liana Tsenova,Natalia Kurepina,Karen Wei Weng Teng,Kim West,Smriti Mehra,Francesca Zolezzi,Michael Poidinger,Barry Kreiswirth,Deepak Kaushal,Hardy Kornfeld,Evan W. Newell,Amit Singhal,Amit Singhal +22 more
TL;DR: It is shown that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)–dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease, and a potential of SIRT1 activators in designing an effective and clinically relevant host-directed therapies for TB.
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Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection
Ricardo C.H. del Rosario,Jeremie Poschmann,Carey Fang Hui Lim,Catherine Y. Cheng,Pavanish Kumar,Catherine Riou,Seow Theng Ong,Sherif Gerges,Hajira Shreen Hajan,Dilip Kumar,Mardiana Marzuki,Xiaohua Lu,Andrea Lee,Giovani Claresta Wijaya,Nirmala Arul Rayan,Zhong Zhuang,Elsa Du Bruyn,Cynthia B.E. Chee,Bernett Lee,Josephine Lum,Francesca Zolezzi,Michael Poidinger,Rotzschke,Chiea Chuen Khor,Robert J. Wilkinson,Yee Tang Wang,George K. Chandy,Gennaro De Libero,Amit Singhal,Shyam Prabhakar +29 more
TL;DR: A histone acetylome-wide association study (HAWAS) of an infectious disease, on the basis of genome-wide H3K27 acetylation profiling of peripheral blood granulocytes and monocytes from persons with active Mycobacterium tuberculosis (Mtb) infection and healthy controls, was described in this article .
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Broad-Spectrum Antimicrobial Star Polycarbonates Functionalized with Mannose for Targeting Bacteria Residing inside Immune Cells.
Chuan Yang,Sangeetha Krishnamurthy,Jie Liu,Shaoqiong Liu,Xiaohua Lu,Daniel J. Coady,Wei Cheng,Gennaro De Libero,Gennaro De Libero,Amit Singhal,James L. Hedrick,Yi Yan Yang +11 more
TL;DR: The optimal mannose‐functionalized polymer demonstratesMannose receptor‐mediated intracellular bactericidal activity against BCG mycobacteria without inducing cytotoxicity on mammalian cells at the effective dose.