Xiaohua Chen
Wuhan University
5 Papers
9 Citations
Xiaohua Chen is an academic researcher from Wuhan University. The author has contributed to research in topics: Regulation of gene expression & Gene expression profiling. The author has an hindex of 5, co-authored 5 publications.
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Papers
RNA-Seq Identifies Key Reproductive Gene Expression Alterations in Response to Cadmium Exposure
TL;DR: The findings suggest that the reproductive toxicity by cadmium exposure is implicated in multiple layers of deregulation of several biological processes and transcriptional regulation in mice.
The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population
Xiaohua Chen,Hua Du,Binjian Liu,Li Zou,Wei Chen,Yang Yang,Ying Zhu,Yajie Gong,Jianbo Tian,Feng Li,Shan Zhong +10 more
TL;DR: The results suggested these four SNPs in SF3A1 were not associated with CRC risk in a Chinese population, however, further more studies are needed to confirm the findings.
Genome-wide characterization of lncRNAs in acute myeloid leukemia.
Lijun Lei,Siyu Xia,Dan Liu,Xiaoqing Li,Jing Feng,Yaqi Zhu,Jun Hu,Linjian Xia,Lieping Guo,Fei Chen,Hui Cheng,Ke Chen,Hanyang Hu,Xiaohua Chen,Feng Li,Shan Zhong,Nupur Mittal,Guohua Yang,Zhijian Qian,Leng Han,Chunjiang He +20 more
TL;DR: Of the identified lncRNAs, it is found that high expression level lncRNA LOC285758 is associated with the poor prognosis in AML patients and regulates proliferation of AML cell lines by enhancing the expression of HDAC2, a key factor in carcinogenesis.
Integrated analysis of long non-coding RNAs in human colorectal cancer
TL;DR: A new framework for lncRNAs associated clinical prognosis evaluation and target selection of gene therapy in CRC is provided, which identified primary and metastasis tumor linked lncRNA signatures positively correlated with poor-prognosis gene set.
E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C
Xiaohua Chen,Jun Xian Loo,Xin Shi,Wenjun Xiong,Yong Guo,Haiqiang Ke,Mingkun Yang,Yanping Jiang,Siyu Xia,Min Zhao,Shan Zhong,Chunjiang He,Li Fu,Feng Li +13 more
TL;DR: A novel explanation for why infections with certain HPV isotypes are associated with elevated cancer risk is suggested by identifying an epigenetic mechanism through which E6 proteins expressed by those isotypes can drive expression of key oncogenes.