Xiaohan Xu
Ocean University of China
9 Papers
10 Citations
Xiaohan Xu is an academic researcher from Ocean University of China. The author has contributed to research in topics: Medicine & Proinflammatory cytokine. The author has an hindex of 3, co-authored 5 publications.
Chat about Author
Papers
A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator.
Fan Su,Qiaoling Song,Chuanliang Zhang,Xiaohan Xu,Mengyuan Li,Dan Yao,Wu Lijuan,Qu Xianjun,Huashi Guan,Guangli Yu,Jinbo Yang,Chenyang Zhao +11 more
TL;DR: The data suggest that a β-1,3/1,6-glucan derived from marina alga Durvillaea antarctica (BG136) might act as an immune stimulator to exert antitumor effects in vivo.
33
Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling.
Lei Zhang,Qiaoling Song,Xinxin Zhang,Li Li,Ximing Xu,Xiaohan Xu,Xiaoyu Li,Zhuoya Wang,Yuxi Lin,Xin Li,Mengyuan Li,Fan Su,Xin Wang,Peiju Qiu,Huashi Guan,Tang Yu,Wenfang Xu,Jinbo Yang,Chenyang Zhao +18 more
TL;DR: The present study identifies Zelnorm as a novel JAK/STAT3 signaling inhibitor and reveals a new clinical application of Zelnorm upon market reintroduction.
18
Unfolded Protein Response Differentially Regulates TLR4-Induced Cytokine Expression in Distinct Macrophage Populations.
Lei Zhang,Paul G. Pavicic,Shyamasree Datta,Qiaoling Song,Xiaohan Xu,Wei Wei,Fan Su,Patricia Rayman,Chenyang Zhao,Chenyang Zhao,Thomas A. Hamilton +10 more
TL;DR: It is reported that macrophages in distinct states of differentiation or in different temporal stages of inflammatory response exhibit differential sensitivity to cell stress mediated alterations in M1-like polarized inflammatory cytokine production, suggesting that cellular stress can be an important modulator of the magnitude and character of myeloid inflammatory activity.
Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization
Qiaoling Song,Shyamasree Datta,Xue Liang,Xiaohan Xu,Paul G. Pavicic,Xiaonan Zhang,Yuanyuan Zhao,Shan Liu,Jun Zhao,Yuting Xu,Jing Xu,Lihong Wu,Zhihua Wu,Minghui Zhang,Zhan Zhao,Chunhua Lin,Yuxin Wang,Peng Han,Peng Jiang,Yating Qin,Wei Li,Yingying Zhang,Yonglun Luo,Ganes C. Sen,George R. Stark,Chenyang Zhao,Thomas A. Hamilton,Jinbo Yang +27 more
TL;DR: Overall, the heterogeneity of hepatic myeloid cells in APAP-ALI is uncovered at single-cell resolution and the therapeutic potential of IFN-I in the treatment of AP AP-ALi is uncovered.
14
A Novel Blood–Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis
TL;DR: In this paper , the authors designed a novel vascular-targeting and blood-brain barrier (BBB)-penetrating peptide, TAT-AT7, by attaching the cell-penetrated peptide TAT to a vascular targeting peptide AT7, and demonstrated that TAT could target binding to the vascular endothelial growth factor receptor 2 (VEGFR-2) and Neuropilin-1 (NRP-1), which are both highly expressed in endothelial cells.