Xiaofeng Zhang
University of Texas Medical Branch
29 Papers
102 Citations
Xiaofeng Zhang is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Ehrlichia chaffeensis & Ehrlichia canis. The author has an hindex of 19, co-authored 27 publications.
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Papers
Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements
TL;DR: It is determined by confocal immunofluorescence microscopy and by immunodetection in purified nuclear extracts that the ankyrin repeat-containing protein p200 is translocated to the nuclei of Ehrlichia-infected monocytes, the first study to identify a nuclear translocation of bacterially encoded protein by E. chaffeensis.
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Identification of a glycosylated Ehrlichia canis 19-kilodalton major immunoreactive protein with a species-specific serine-rich glycopeptide epitope.
Jere W. McBride,C. Kuyler Doyle,Xiaofeng Zhang,Ana Maria Cardenas,Vsevolod L. Popov,Kimberly A. Nethery,Michael E. Woods +6 more
TL;DR: The gp19 protein was present on reticulate and dense-cored cells, and it was found extracellularly in the fibrillar matrix and associated with the morula membrane, the host cell cytoplasm, and the nucleus.
Genetic and Antigenic Diversities of Major Immunoreactive Proteins in Globally Distributed Ehrlichia canis Strains
Xiaofeng Zhang,Tian Luo,Avi Keysary,Gad Baneth,Simone Miyashiro,Carmela Strenger,Trevor Waner,Jere W. McBride +7 more
TL;DR: Two distinct E. canis strains were demonstrated, defined by the gp36 gene, which demonstrated highly conserved immunoreactive protein profiles, while some differences were identified in the IS strain.
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Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae).
TL;DR: The egg clutches laid by four engorged adult females, and the larvae that hatched from these eggs along with larvae from a previously untested egg clutch, were shown to be uninfected by PCR, which seems to support the long-held assumption of lack of transovarial transmission.
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Enzyme-Linked Immunosorbent Assay with Conserved Immunoreactive Glycoproteins gp36 and gp19 Has Enhanced Sensitivity and Provides Species-Specific Immunodiagnosis of Ehrlichia canis Infection
Ana Maria Cardenas,C. Kuyler Doyle,Xiaofeng Zhang,Kimberly A. Nethery,Richard E. Corstvet,Richard E. Corstvet,David H. Walker,Jere W. McBride +7 more
TL;DR: Recombinant polypeptides gp36, gp19, and gp200 exhibited 100% sensitivity and specificity for immunodiagnosis by the recombinant glycoprotein ELISA compared with the results obtained by an indirect fluorescent-antibody assay (IFA) for the detection of antibodies in dogs that were naturally infected with E. canis.
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