Chemotherapy is an important anti-tumor treatment in clinic to date, however, the effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic toxicity, and multidrug resistance. In recent years, mesoporous silica nanoparticles (MSNs) have become exciting drug delivery systems (DDS) due to their unique advantages, such as easy large-scale production, adjustable uniform pore size, large surface area and pore volumes. While mesoporous silica-based DDS can improve chemotherapy to a certain extent, when used in combination with other cancer therapies MSN based chemotherapy exhibits a synergistic effect, greatly improving therapeutic outcomes. In this review, we discuss the applications of MSN DDS for a diverse range of chemotherapeutic combination anti-tumor therapies, including phototherapy, gene therapy, immunotherapy and other less common modalities. Furthermore, we focus on the characteristics of each nanomaterial and the synergistic advantages of the combination therapies. Lastly, we examine the challenges and future prospects of MSN based chemotherapeutic combination therapies.

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A Review of Mesoporous Silica Nanoparticle Delivery Systems in Chemo-Based Combination Cancer Therapies

Current trends in smart mesoporous silica-based nanovehicles for photoactivated cancer therapy.

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. Over the past two decades, researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques, demonstrating their adaptability to various biomedical application scenarios. With the continuous breakthroughs of MSNs in the fields of biosensing, disease diagnosis and treatment, tissue engineering, etc., MSNs are gradually moving from basic research to clinical trials. In this review, we provide a detailed summary of MSNs in the biomedical field, beginning with a comprehensive overview of their development history. We then discuss the types of MSNs-based nanostructured architectures, as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components. Subsequently, we summarize the primary purposes of surface-functionalized modifications of MSNs. In the following, we discuss the biomedical applications of MSNs, and highlight the MSNs-based targeted therapeutic modalities currently developed. Given the importance of clinical translation, we also summarize the progress of MSNs in clinical trials. Finally, we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field. 

Multifunctional mesoporous silica nanoparticles for biomedical applications

Advanced nanotechnology has been emerging rapidly in terms of novel hybrid nanomaterials that have found various applications in day-to-day life for the betterment of the public. Specifically, gold, iron, silica, hydroxy apatite, and layered double hydroxide based nanohybrids have shown tremendous progress in biomedical applications, including bio-imaging, therapeutic delivery and photothermal/dynamic therapy. Moreover, recent progress in up-conversion nanohybrid materials is also notable because they have excellent NIR imaging capability along with therapeutic benefits which would be useful for treating deep-rooted tumor tissues. Our present review highlights recent developments in inorganic–inorganic nanohybrids, and their applications in bio-imaging, drug delivery, and photo-therapy. In addition, their future scope is also discussed in detail.

/pdf/inorganic-inorganic-nanohybrids-for-drug-delivery-imaging-1iy99m95eq.pdf

Inorganic-inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope.

The role of imaging in targeted delivery of nanomedicine for cancer therapy.

Mesoporous silica nanospheres as nanocarriers for poorly soluble drug itraconazole with high loading capacity and enhanced bioavailability

Synergistic therapy with high efficacy and low side effects is of great significance in cancer treatment, and therefore the elaborate design of advanced nanocarriers to benefit diverse loading requirements of size-varied therapy agents is of critical importance. Herein, we demonstrate a multifunctional drug carrier platform based on a hierarchical porous and –NH2-modified silica nanocarrier (FMSN) with a super high specific surface area and a large pore volume, which not only improves the loading capacity of both doxorubicin, a chemotherapeutic drug, and black phosphorus quantum dots (BPQDs), a kind of biocompatible photothermal agent, but also enhances the photothermal stability and biostability of the degradable BPQDs. The unique structure and surface design enable our multimodal platform with heat-stimulative, pH-responsive and sustained-release properties for chemo-photothermal synergistic cancer therapy. Both cytotoxicity experiments and in vivo study reveal that the combined therapy based on our multifunctional nanohybrids mediates the highest death rate of cancer cells compared to that of single chemotherapy or photothermal therapy. Our hierarchical mesoporous strategy provides an excellent drug delivery model for advanced chemo-photothermal synergistic targeted cancer therapy.

Multifunctional hierarchical mesoporous silica and black phosphorus nanohybrids as chemo-photothermal synergistic agents for enhanced cancer therapy.

The invention discloses a mesoporous silica nanosphere, a preparation method thereof, and an application of the nanosphere in drug load. The preparation method comprises the following steps: adding asilicon source solution composed of a silicone source and a diluent to a mixed aqueous solution containing a surfactant, a catalyst and a diluent, stirring and reacting the obtained solution, filtering the obtained solution, washing the obtained reaction product, and calcining the washed reaction product. The prepared sample has a particle size of 40-200 nm, a specific surface area of 1050-1350m /g and a pore size of 1.8-2.4 nm; and the product is applied to the loading of hydrophobic drugs to achieve nanocrystallization of the drugs and enhance the water solubility and the dissolution rate. The method provided by the invention has the advantages of avoiding of the use of an organic template for traditional mesoporous silica nanospheres, easily available raw materials, simple device and high efficiency; and introduction of pore wall particles to the mesoporous structure facilitates diffusion and load of drugs, reduces rerystallization, and makes the in vitro dissolution rate be almost 100%, so the drugs have significantly higher bioavailability than commercial drugs, and have great actual significance.

Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load

The invention provides a hollow silicon dioxide nanometer sphere and a preparation method and application thereof. The preparation method of the hollow silicon dioxide nanometer sphere comprises the following steps that 1, a silicon source precursor is added into a solution containing a carbon sphere template agent, a catalyst, a dispersing agent and a surface active agent for a stirring reactionfor 3-4 h; the dispersing agent is ethyl alcohol and water; 2, the solution obtained in step 1 is subjected to a hydrothermal reaction under the temperature of 150-200 DEG C. The preparation method can obtain the hollow silicon dioxide nanometer sphere containing communicated macropore and mesopore structures, and the hollow silicon dioxide nanometer sphere is of the grading hole structure and isin a raspberry shape. The preparation method is easy and efficient to implement.

Hollow silicon dioxide nanometer sphere and preparation method and application thereof

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Mesoporous silica nanospheres as nanocarriers for poorly soluble drug itraconazole with high loading capacity and enhanced bioavailability

Multifunctional hierarchical mesoporous silica and black phosphorus nanohybrids as chemo-photothermal synergistic agents for enhanced cancer therapy.

Mesoporous silica nanosphere, preparation method thereof, and application of nanosphere in drug load

Hollow silicon dioxide nanometer sphere and preparation method and application thereof