Xiaofei Xin
China Pharmaceutical University
22 Papers
6 Citations
Xiaofei Xin is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 6, co-authored 10 publications.
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Papers
Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells
Yaqi Lv,Chaoran Xu,Xiangmei Zhao,Chenshi Lin,Xin Yang,Xiaofei Xin,Li Zhang,Chao Qin,Xiaopeng Han,Lei Yang,Wei He,Lifang Yin +11 more
TL;DR: Overall, these findings indicate that a prodrug of an HA-hydrophobic-active compound and liposomes can be self-assembled into a smart nanoplatform for the dual targeting of the TME and tumor cells and efficient combined treatment.
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Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer
TL;DR: The present nanocarrier co-loading with DTX and miRNA-34a is a new nanoplatform for the combination of insoluble drugs and gene/protein drugs and provides a promising strategy for the treatment of metastatic breast cancer.
Rod-Shaped Active Drug Particles Enable Efficient and Safe Gene Delivery.
TL;DR: In this article, a rod-shaped active pure drug nanoparticles (PNPs) with a dramatically high drugloading of ≈300% as vectors is reported, which can enter cells and bypass the lysosomal route to localize to the cytosol, achieving efficient intracellular delivery of let-7a and a 50% reduction in expression of the target protein.
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Drug-delivering-drug platform-mediated potent protein therapeutics via a non-endo-lysosomal route.
TL;DR: This platform gains cellular entry without entrapment in the endo-lysosomes and enables efficient intracellular protein delivery and resultant profound cancer treatment and offers a robust and safe approach for protein therapeutics and intrACEllular delivery of other functional peptides, as well as gene-based therapy.
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Rod‐Shaped Drug Particles for Cancer Therapy: The Importance of Particle Size and Participation of Caveolae Pathway
TL;DR: This study highlights the importance of the size of the PTX‐Ns and the participation of caveolae‐mediated endocytosis in controlling their biological functions and will assist in the design and optimization of new nanosuspension formulations for disease therapy.
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