Xiaocui Xu
Chinese Academy of Sciences
11 Papers
Xiaocui Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Reprogramming. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Xiaocui Xu include Beijing Institute of Genomics.
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Papers
DNA methylation reprogramming of functional elements during mammalian embryonic development
Congru Li,Congru Li,Congru Li,Yong Fan,Guoqiang Li,Xiaocui Xu,Xiaocui Xu,Jialei Duan,Rong Li,Xiangjin Kang,Xin Ma,Xin Ma,Xuepeng Chen,Xuepeng Chen,Yuwen Ke,Jie Yan,Ying Lian,Ping Liu,Yue Zhao,Hongcui Zhao,Yaoyong Chen,Yang Yu,Jiang Liu,Jiang Liu +23 more
TL;DR: It is shown that the dynamics of DNA methylation in functional elements are conserved between humans and mice during early embryogenesis, except for satellite repeats, and the hypothesis thatDNA methylation plays important roles during mammalian development is supported.
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition
You Wu,Xiaocui Xu,Meijie Qi,Chuan Chen,Mengying Li,Rushuang Yan,Xiaochen Kou,Yanhong Zhao,Wenqiang Liu,Yanhe Li,Xuelian Liu,Meiling Zhang,Chengqi Yi,Hongbin Liu,Junhong Xiang,Hong Wang,Bin Shen,Yawei Gao,Shaorong Gao +18 more
TL;DR: In this article , the authors developed a method of ultralow-input m6A RNA immunoprecipitation followed by sequencing to reveal the transcriptome-wide m6As landscape in mouse oocytes and early embryos and found unique enrichment and dynamics of m6a RNA modifications on maternal and zygotic RNAs, including the transcripts of transposable elements MTA and MERVL.
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation.
Xiaoying Zhang,Dandan Cao,Liting Xu,Yanhua Xu,Zehua Gao,Yuanzhong Pan,Ming Jiang,Yuhui Wei,Lihua Wang,Yue Liao,Qiang Wang,Lei Yang,Xiaocui Xu,Yawei Gao,Shaorong Gao,Jing Wang,Rui Yue +16 more
TL;DR: In this article , the authors showed that matrix stiffness fine-tuned HSC niche factor expression by bone marrow stromal cells (BMSCs), which could be harnessed to engineer a soft bone marrow niche for HSC rejuvenation.
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Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming
Chenxiang Xi,Jiatong Sun,Xiaocui Xu,You Wu,Xiaochen Kou,Yanhong Zhao,Jiachen Shen,Yu Dong,Kang Chen,Zhongqu Su,Dan Liu,W. Ye,Yingdong Liu,Ran Zhang,Yiliang Xu,Hong Wang,Lujiang Hao,Li Wu,Shaorong Gao +18 more
TL;DR: In this paper , Mettl14, another component of the methyltransferase complex, can significantly enhance the generation of induced pluripotent stem cells (iPSCs) in an m6A-independent manner.
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Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq
Lingyue Yang,Xiaocui Xu,Ruimin Xu,Chuan Chen,Xiaolei Zhang,Mo Chen,Xiaochen Kou,Yanhong Zhao,Hong Wang,Xiaoyu Liu,Shaorong Gao,Chong Li +11 more
TL;DR: In this paper , the authors mapped genome-wide nucleosome profiles in mouse SCNT embryos using ultra-low-input MNase-seq (ULI-MNaseseq) and found that the nucleosomes-depleted regions around promoters underwent dramatic reestablishment, which is consistent with the cell cycle.
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