Xiaochen Lin
University of Connecticut
8 Papers
8 Citations
Xiaochen Lin is an academic researcher from University of Connecticut. The author has contributed to research in topics: Prodrug & Integrin. The author has an hindex of 4, co-authored 8 publications.
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Papers
Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes.
Chia-Hung Christine Hsiao,Xiaochen Lin,Rocky J. Barney,Rebekah R. Shippy,Jin Li,Olga Vinogradova,David F. Wiemer,Andrew J. Wiemer +7 more
TL;DR: The pivaloyloxymethyl prodrug is the most potent phosphoantigen described to date, with stronger stimulation of Vγ9Vδ2 T cells from human peripheral blood and greater ability to induce lysis of Daudi lymphoma cells relative to the previously most potent compound, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP).
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Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism.
Rebekah R. Shippy,Xiaochen Lin,Sherry S Agabiti,Jin Li,Brendan M. Zangari,Benjamin J. Foust,Michael M. Poe,Chia-Hung Christine Hsiao,Olga Vinogradova,David F. Wiemer,Andrew J. Wiemer +10 more
TL;DR: Together, tris-POM prodrugs enhance the cellular activity of phosphinophosphonates, reveal structure-activity relationships of butyrophilin ligands, and support a negatively cooperative model of cellular butyphilin activation.
Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling
Xiaochen Lin,Olga Vinogradova +1 more
TL;DR: The Shc adaptor protein, particularly its p52 isoform, has been identified as a primary signaling partner for the tyrosine(s)-phosphorylated cytoplasmic tails of activated β3 integrins.
Targeting Integrin-Dependent Adhesion and Signaling with 3-Arylquinoline and 3-Aryl-2-Quinolone Derivatives: A new Class of Integrin Antagonists.
Sandrine Fiorucci,Xiaochen Lin,Karin Sadoul,Guy Fournet,Daniel Bouvard,Olga Vinogradova,Benoît Joseph,Marc R. Block +7 more
TL;DR: 3-arylquinoline and 3-aryl-2-quinolone series are a novel class of integrin activation and signaling antagonists.
Skelemin association with αIIbβ3 integrin: a structural model.
Vitaliy Gorbatyuk,Khiem Nguyen,Nataly P. Podolnikova,Lalit Deshmukh,Xiaochen Lin,Tatiana P. Ugarova,Olga Vinogradova +6 more
TL;DR: A structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3 is presented and illuminates a potential link between the essential cell adhesion receptors and myosin filaments that may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling.
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