Xiaochen Gao
Huazhong Agricultural University
11 Papers
Xiaochen Gao is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production
Ruifang Wang,Yinxing Zhu,Xian Lin,Chenwei Ren,Jiachang Zhao,Fangfang Wang,Xiaochen Gao,Rong Xiao,Lianzhong Zhao,Huanchun Chen,Meilin Jin,Wenjun Ma,Hongbo Zhou +12 more
TL;DR: This work showed that M2 protein colocalized and interacted with MAVS (mitochondrial antiviral signaling protein) on mitochondria, and positively regulated MAVS-mediated innate immunity, and uncovered a new mechanism into biology and pathogenicity of influenza A virus.
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TFAM-Dependent Mitochondrial Metabolism Is Required for Alveolar Macrophage Maintenance and Homeostasis
TL;DR: The data have established the critical function of TFAM-mediated mitochondrial metabolism in AM maintenance and function and found that influenza virus infection in AMs led to impaired TFAM expression and diminished mitochondrial fitness and metabolism.
26
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Qingxia Gao,Cha Yang,Caiyue Ren,Shishuo Zhang,Xiaochen Gao,Meilin Jin,Huanchun Chen,Wenjun Ma,Hongbo Zhou +8 more
TL;DR: EEF1D was identified as a novel inhibitor for the influenza virus life cycle and impaired the interaction between NP and importin α5 and the interactionBetween PB1 and RanBP5, which impeded the nuclear import of vRNP.
26
H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells.
Chengcheng Liu,Xinhao Wu,Xin Bing,Wenwen Qi,Fang Qing Zhu,Na Guo,Xiaochen Gao,Miaoqing Zhao,M. Xia +8 more
TL;DR: In this paper , the causes and mechanisms of nasal mucosa epithelial cell death caused by Influenza A virus H1N1 infection were investigated, and the role of the NRF2-KEAP1-GCLC signaling pathway in H 1N1 virus-induced ferroptosis was determined.
12
JEV Infection Induces M-MDSC Differentiation Into CD3+ Macrophages in the Brain
TL;DR: Evidence is provided for the mechanism that JEV regulates the differentiation of M-MDSCs and thereby exacerbates pathogenicity, which represents a potential therapeutic target for Japanese encephalitis (JE).