Xiaobo Wu
Washington University in St. Louis
40 Papers
255 Citations
Xiaobo Wu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Complement system & Alternative complement pathway. The author has an hindex of 19, co-authored 35 publications.
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Papers
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C. Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Philip A. Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: In this article, the authors investigated complement activation in the plasma from patients with COVID-19 prospectively enrolled at two tertiary care centers: Washington University School of Medicine (n=134) and Yale Medical Center(n=49) and compared their patients to two non-COVID cohorts: (a) patients hospitalized with influenza and (b) patients admitted to the ICU with acute respiratory failure requiring invasive mechanical ventilation (IMV, n=22).
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Complement-Dependent Neutrophil Recruitment Is Critical for the Development of Elastase-Induced Abdominal Aortic Aneurysm
Monica B. Pagano,Hui-fang Zhou,Terri L. Ennis,Xiaobo Wu,John D. Lambris,John P. Atkinson,Robert W. Thompson,Dennis E. Hourcade,Christine T. N. Pham +8 more
TL;DR: The identification of involvement of the complement system in the pathophysiology of AAA provides a new target for therapeutic intervention in this common disease.
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Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
Lina Ma,Sanjaya Kumar Sahu,Marlene Cano,Vasanthan Kuppuswamy,Jamal Bajwa,Jamal Bajwa,Ja’Nia McPhatter,Ja’Nia McPhatter,Alexander B Pine,Matthew L Meizlish,George Goshua,C-Hong Chang,Hanming Zhang,Christina Price,Parveen Bahel,Henry M. Rinder,Tingting Lei,Aaron Day,Daniel Reynolds,Xiaobo Wu,Rebecca E Schriefer,Adriana M Rauseo,Charles W. Goss,Jane A. O’Halloran,Rachel M. Presti,Alfred H.J. Kim,Andrew E. Gelman,Charles S. Dela Cruz,Alfred Ian Lee,Phillip Mudd,Hyung J. Chun,John P. Atkinson,Hrishikesh S. Kulkarni +32 more
TL;DR: Increased complement activation in COVID-19 compared to influenza and non-COVID respiratory failure is reported, and alternative pathway activation is demonstrated as a key marker of multiorgan failure and death.
Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development.
Xiaobo Wu,Ning Jiang,Yi-Fu Fang,Chenguang Xu,Dailing Mao,Jasvinder Singh,Yang Xin Fu,Hector Molina +7 more
TL;DR: Observations indicate that immunization with inflammatory Ags offset some of the immunological abnormalities found in the Cr2−/− mice and show that optimal affinity maturation can be achieved in the absence of normal germinal centers.
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Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm
Hui-fang Zhou,Huimin Yan,Cordula M. Stover,Tamara Montes Fernandez,Santiago Rodríguez de Córdoba,Wen-Chao Song,Xiaobo Wu,Robert W. Thompson,Wilhelm J. Schwaeble,John P. Atkinson,Dennis E. Hourcade,Christine T. N. Pham +11 more
TL;DR: It is shown that properdin is required for the development of elastase-induced AAA in its primary role as a convertase stabilizer and that blockade of properdin activity prevents aneurysm formation, indicating that an innate immune response to self-antigens activates the complement system and initiates the inflammatory cascade in AAA.
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