Xiao Yu

TL;DR: The identification of a bidentate salicylic acid-based Lyp inhibitor I-C11 with excellent cellular efficacy is reported and established a mechanism by which PKC could attenuate the cellular function of Lyp, thereby augmenting T cell activation.

TL;DR: Cryo-electron microscopy structures of GPBAR–G s complexes revealed a large oval pocket that contains several polar groups positioned to accommodate the amphipathic cholic core of bile acids, a fingerprint of key residues to recognize diverse bile acid in the orthosteric site, and the presence of distinct connecting mechanisms between the ligand-binding pocket and the G-protein-binding site in the G -protein-coupled receptor superfamily.

TL;DR: A higher expression of JAML in glomeruli from subjects with DKD and other types of proteinuric kidney diseases, and the level of J AML was correlated with lipid accumulation and glomerular filtration rate, suggesting that JAMl may be an attractive therapeutic target for proteinurIC kidney disease.

TL;DR: The authors showed that glucocorticoid stress hormones activate adhesion G-protein-coupled receptor G3 (ADGRG3; also known as GPR97)4-6, a prototypical GPCR.