Xiao Yang
16 Papers
Xiao Yang is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 7 publications.
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Papers
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
Xiao Yang,Yan Chen,Jiadong Guo,Jiaxin Li,Pu Zhang,Huanming Yang,Kewei Rong,Tangjun Zhou,Jingke Fu,Jie‐Zu Zhao +9 more
TL;DR: In this article , polydopamine nanoparticles (PDA NPs) were shown to inhibit oxidative stress-induced ferroptosis in nucleus pulposus (NP) cells in vitro.
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DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1‐Mediated NRF2 Ubiquitination
Xin Wang,Tangjun Zhou,Xiao Yang,Xiankun Cao,Gu Jin,Pu Zhang,Jiadong Guo,Kewei Rong,Baixing Li,Kexin Liu,Peixiang Ma,An Qin,Jie‐Zu Zhao +12 more
TL;DR: In this article , the authors found that DDRGK domain-containing protein 1 (DDRGK1) plays a fundamental role in chemoresistance induced in osteosarcoma.
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Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
Huanming Yang,Xiao Yang,Kewei Rong,Jiarong Liang,Zheng-Yu Wang,Jie‐Zu Zhao,Pu Zhang,Yijie Li,Lihuan Wang,Hui Ma,Bin Ye +10 more
TL;DR: In this article , the role of eupatilin in tumor necrosis factor-α (TNF-α)-induced activation of inflammatory signaling pathways and NP cell senescence, in the anabolism and catabolism of NP cell extracellular matrix (ECM) and in the effect of the puncture-induced model of caudal IDD in the rat.
Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis.
Pu Zhang,Kewei Rong,Jiadong Guo,Lei Cui,Keyu Kong,Chen Zhao,Huanming Yang,Hongtao Xu,An Qin,Peixiang Ma,Xiao Yang,Jie‐Zu Zhao +11 more
- 01 Aug 2023
TL;DR: Cynarin, a natural product enriched in Artichoke, was discovered to inhibit ferroptosis of nucleus pulposus cells and is a potential candidate for the drug development for IVDD.
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Engeletin Alleviates the Inflammation and Apoptosis in Intervertebral Disc Degeneration via Inhibiting the NF-κB and MAPK Pathways
Baixing Li,Xiao Yang,Pu Zhang,Jiadong Guo,Kewei Rong,Xin Wang,Xiankun Cao,Tangjun Zhou,Jie‐Zu Zhao +8 more
TL;DR: It is found that the activation of MAPK and NF-κB signaling pathways and the nuclear translocation of phosphorylated p65 and p38 were inhibited prominently with the treatment of engeletin which may be the potential molecular mechanism for its anti-inflammation effects.
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