Xiao Wang
Shanghai Jiao Tong University
35 Papers
142 Citations
Xiao Wang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Insulin & Downregulation and upregulation. The author has an hindex of 13, co-authored 35 publications.
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Papers
Berberine stimulates glucose transport through a mechanism distinct from insulin.
Libin Zhou,Ying Yang,Xiao Wang,Shangquan Liu,Wenbin Shang,Guoyue Yuan,Fengying Li,Jinfeng Tang,Ming-Dao Chen,Jia-Lun Chen +9 more
TL;DR: It was revealed that berberine stimulated glucose uptake in 3T3-L1 adipocytes in a dose- and time-dependent manner with the maximal effect at 12 hours, and activated adenosine monophosphate-activated protein kinase seems to be involved in the metabolic effect of berberines.
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Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction☆
Ling Wu,Libin Zhou,Yan Lu,Juan Zhang,Fang-fang Jian,Yun Liu,Fengying Li,Wenyi Li,Xiao Wang,Guo Li +9 more
TL;DR: It is demonstrated that SIRT1 mRNA and protein expressions were markedly reduced in the islets isolated from rats infused with 20% Intralipid for 24h, indicating that Sirt1 protects against palmitate-induced β-cell dysfunction.
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The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to β-cell function.
Yuqing Zhang,Feiye Zhou,Mengyao Bai,Yun Liu,Linlin Zhang,Qin Zhu,Yufang Bi,Guang Ning,Libin Zhou,Xiao Wang +9 more
TL;DR: The first large-scale profiling of acetylome in rat islets was performed, showing that almost all enzymes in core metabolic pathways related to insulin secretion were acetylated, highlighting the potential role of protein acetylation in insulin secretion.
Berberine Suppresses Adipocyte Differentiation via Decreasing CREB Transcriptional Activity
Juan Zhang,Hongju Tang,Ruyuan Deng,Ning Wang,Yuqing Zhang,Yao Wang,Yun Liu,Fengying Li,Xiao Wang,Libin Zhou +9 more
TL;DR: It is found that berberine significantly suppressed the expressions of CCAAT/enhancer-binding protein (C/EBP)α, peroxisome proliferators-activated receptor γ2 (PPARγ2), and other adipogenic genes in the process of adipogenesis.
Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes.
Libin Zhou,Xiao Wang,Ying Yang,Ling Wu,Fengying Li,Rong Zhang,Guoyue Yuan,Ning Wang,Ming-Dao Chen,Guang Ning +9 more
TL;DR: It is suggested that berberine exerts an antilipolytic effect mainly by reducing the inhibition of PDE, leading to a decrease in cAMP and HSL phosphorylation independent of AMPK pathway.
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