Xiao Wang
Fudan University
18 Papers
Xiao Wang is an academic researcher from Fudan University. The author has contributed to research in topics: Myeloid-derived Suppressor Cell & Innate immune system. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of Xiao Wang include Fudan University Shanghai Medical College & Beijing Normal University.
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Papers
SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
Guangwei Liu,Yujing Bi,Bo Shen,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Jiongbo Liao,Xi Chen,Yiwei Chu +10 more
TL;DR: It is found that SIRT1 deficiency in MDSCs directs a specific switch to M1 lineage when cells enter the periphery from bone marrow, decreasing the suppressive function in favor of a proinflammatory M1 phenotype associated with tumor cell attack.
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HIF1α-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection
Chunxiao Li,Yu Wang,Yu Wang,Yan Li,Yan Li,Qing Yu,Xi Jin,Xiao Wang,Xiao Wang,Anna Jia,Ying Hu,Linian Han,Jian Wang,Jian Wang,Hui Yang,Dapeng Yan,Yujing Bi,Guangwei Liu,Guangwei Liu +18 more
TL;DR: It was found that bacterial and fungal infections produced similar effects on macrophage functional differentiation, and Alteration of glycolytic pathway activation was required for the functional differentiation of pro-inflammatory macrophages in protecting against bacterial andfungal infections.
Targeting S1P1 Receptor Protects against Murine Immunological Hepatic Injury through Myeloid-Derived Suppressor Cells
Guangwei Liu,Yujing Bi,Ruoning Wang,Ruoning Wang,Hui Yang,Yan Zhang,Xiao Wang,Huanrong Liu,Yun Lu,Zhengguo Zhang,Wanna Chen,Yiwei Chu,Ruifu Yang +12 more
TL;DR: MDSCs are identified as an essential component that provides protection against IMH following FTY720 or rapamycin treatment, validating the S1P1–mTOR signaling axis as a potential therapeutic target in hepatic injury.
Cancer-Associated Fibroblasts Positively Correlate with Dedifferentiation and Aggressiveness of Thyroid Cancer.
Shishuai Wen,Ning Qu,Ben Ma,Xiao Wang,Yi Luo,Weibo Xu,Hongyi Jiang,Yan Zhang,Yu Wang,Qinghai Ji +9 more
TL;DR: Wang et al. as discussed by the authors investigated correlations of cancer-associated fibroblast (CAF) with dedifferentiation and clinicopathological characteristics of thyroid cancer and found that high CAF score showed a significant correlation with the anaplastic phenotype in DDTC and low thyroid differentiation score in PTC.
Clinical, Pathological, and Molecular Characteristics Correlating to the Occurrence of Radioiodine Refractory Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Yi Luo,Yi Luo,Hongyi Jiang,Hongyi Jiang,Weibo Xu,Weibo Xu,Xiao Wang,Xiao Wang,Ben Ma,Ben Ma,Tian Liao,Yu Wang,Yu Wang +12 more
TL;DR: Histological subtype, ETE, BRAFV600E mutation, and TERT promoter mutation could be considered clinicopathological factors and biomarkers that could assist in risk stratification, prognostic prediction, and individual therapy options for RR-DTC.