Xiao-Ming Xia
Washington University in St. Louis
41 Papers
126 Citations
Xiao-Ming Xia is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: BK channel & Gating. The author has an hindex of 23, co-authored 41 publications. Previous affiliations of Xiao-Ming Xia include University of Washington.
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Papers
Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa.
TL;DR: KSper/Slo3 is the primary spermatozoan K+ current, that KSper may play a critical role in acquisition of normal morphology and sperm motility when faced with hyperosmotic challenges, and that Slo3 is critical for fertility.
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Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites.
TL;DR: The results support the view that three distinct divalent-cation binding sites mediate regulation of BK channels.
The Ca2+-activated K+ current of human sperm is mediated by Slo3
Christoph Brenker,Yu Zhou,Astrid Müller,Fabio Andres Echeverry,Christian Trötschel,Ansgar Poetsch,Xiao-Ming Xia,Wolfgang Bönigk,Christopher J. Lingle,U. Benjamin Kaupp,Timo Strünker +10 more
TL;DR: It is proposed that the progesterone-evoked Ca2+ influx carried by voltage-gated CatSper channels is limited by Ca2-controlled hyperpolarization via Slo3, which represents the principal K+ channel in human sperm that carries the Ca1+-activated IKSper current.
Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.
TL;DR: Differential differences in pharmacological properties of Slo3 and Slo1 currents are defined, blockade in terms of distinct blocking models are examined, and mutated constructs are used to evaluate determinants of block.
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Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents.
Feng Wei,Xiao-Ming Xia,Jianrong Tang,Hushan Ao,Shanelle Ko,Jason Liauw,Chang Shen Qiu,Min Zhuo +7 more
TL;DR: Findings provide strong evidence that CaM is critical for bidirectional synaptic plasticity in adult rodents and may facilitate gene therapy in adult human brains.
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