5 Papers
55 Citations
Xiao Lu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Myeloid leukemia & Myeloid. The author has an hindex of 5, co-authored 5 publications.
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Papers
Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia
Jianbiao Zhou,Chonglei Bi,Ying Qing Ching,Jing Yuan Chooi,Xiao Lu,Jessie Yiying Quah,Sabrina Hui Min Toh,Zit-Liang Chan,Tuan Zea Tan,Phyllis S.Y. Chong,Wee Joo Chng,Wee Joo Chng +11 more
TL;DR: Results uncover a novel mechanism of an important regulatory signaling, LIN28B/let-7/IGF2BP1, in leukemogenesis and provide a rationale to target this pathway as effective therapeutic strategy.
Phosphatase of regenerating liver-3 is regulated by signal transducer and activator of transcription 3 in acute myeloid leukemia.
Jianbiao Zhou,Phyllis S.Y. Chong,Xiao Lu,Lip-Lee Cheong,Chonglei Bi,Shaw-Cheng Liu,Yafeng Zhou,Tuan Zea Tan,Henry Yang,Tae-Hoon Chung,Qi Zeng,Wee Joo Chng +11 more
TL;DR: The STAT3/PRL-3 regulatory loop contributes to the pathogenesis of AML, and it might represent an attractive therapeutic target for antileukemic therapy.
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X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.
TL;DR: It is concluded that the combination of RO‐BIR2 with either TRAIL or Ara‐C represents a potent therapeutic strategy for AML and is warranted for further clinical trials to validate the synergistic benefits in patients with AML, especially for the elderly who are abstaining from intensive chemotherapy.
17
BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia.
TL;DR: This study found that JQ1 is able to reactivate the tumor suppressor gene, TXNIP, and induces apoptosis through the ASK1-MAPK pathway, and provides novel insight on how BET inhibitor can induce apoptosis in AML.
LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML.
Jianbiao Zhou,Zit-Liang Chan,Chonglei Bi,Xiao Lu,Phyllis S.Y. Chong,Jing Yuan Chooi,Lip-Lee Cheong,Shaw-Cheng Liu,Ying Qing Ching,Yafeng Zhou,Motomi Osato,Tuan Zea Tan,Chin Hin Ng,Siok Bian Ng,Shi Wang,Qi Zeng,Wee Joo Chng,Wee Joo Chng +17 more
TL;DR: A novel signaling axis involving PRL-3/LIN28B/let-7, which confers stem cell–like properties to leukemia cells that is important for leukemogenesis is established, which establishes a rationale for targeting PRL -3 as a therapeutic approach for a subset of AML patients with poor prognosis.