Xiao-Dan Qu
University of California, Los Angeles
5 Papers
12 Citations
Xiao-Dan Qu is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Protegrin & Chlamydia trachomatis. The author has an hindex of 4, co-authored 5 publications.
Chat about Author
Papers
Protegrin structure and activity against Neisseria gonorrhoeae.
TL;DR: Structurally simpler protegrin variants, such as PC-64a, could be used as topical microbicides for N. gonorrhoeae and the cystine-stabilized antiparallel beta-sheet formed by PG-1 residues 5 to 16 is principally responsible for its activity against gonococci.
73
Identification of CG-1, a Natural Peptide Antibiotic Derived from Human Neutrophil Cathepsin G:
TL;DR: This study used HPLC to separate the low-molecular-weight peptides derived from the ultrafiltrate of a granule extract from unstimulated PMN and identified the first naturally occurring antibiotic peptide derived from cathepsin G, designated "CG-1".
11
Susceptibility ofNeisseria gonorrhoeaeto Protegrins
Xiao-Dan Qu,Sylvia S. L. Harwig,Ami Oren,William M. Shafer,Androbert I. Lehrer +4 more
- 01 Jan 1996
TL;DR: A novel radial diffusion assay that allowed rapid, reproducible, and quantitative assessment of antimicrobial activity and confirmed the findings by classical colony-counting procedures revealed that under identical assay conditions, gonococci are resistant to human neutrophil defensins but highly susceptible to protegrins.
1
Susceptibility of Neisseria gonorrhoeae to protegrins.
TL;DR: Although each N. gonorrhoeae strain was resistant to human neutrophil defensins, all six were exquisitely sensitive to protegrins, a family of small beta-sheet antimicrobial peptides recently identified in porcine leukocytes, which show promise for development as topical agents to avert sexually transmitted diseases.
Bactericidal properties of murine intestinal phospholipase A2.
TL;DR: Findings identify iPLA2 as part of the antimicrobial arsenal that equips Paneth cells to protect the small intestinal crypts from microbial invasion and this enzyme may also contribute to antibacterial defenses elsewhere in the body.