11 Papers
78 Citations
Xianmin Xia is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Cell growth & PI3K/AKT/mTOR pathway. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Xianmin Xia include Johns Hopkins University & Johns Hopkins Bayview Medical Center.
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Papers
Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation.
TL;DR: The findings suggest that thyroid hormone-regulated target genes may have distinct patterns of coactivator recruitment and histone acetylation that may enable highly specific regulation.
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p55PIK Transcriptionally Activated by MZF1 Promotes Colorectal Cancer Cell Proliferation
TL;DR: It is concluded that p55PIK is transcriptionally activated by MZF1, resulting in increased proliferation of colorectal cancer cells, and may contribute to mitochondrial dysfunction in cancer progression.
Distinct and Histone-Specific Modifications Mediate Positive versus Negative Transcriptional Regulation of TSHα Promoter
TL;DR: Findings show that non-overlapping and specific histone modifications determine positive versus negative transcriptional regulation, and integrate opposing hormonal and intracellular signals at the TSHα promoter.
Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer.
Guihua Wang,Xiaonian Cao,Senyan Lai,Xuelai Luo,Yongdong Feng,Jianli Wu,Qin Ning,Xianmin Xia,Jianhua Wang,Jianping Gong,Junbo Hu +10 more
TL;DR: The study shows that the p53/miR-148b/p55PIK axis has an important role in cell proliferation and tumor growth, and may represent a novel therapeutic target for treating cancers containing p53 mutations or losses.
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PI3K Stimulates DNA Synthesis and Cell-Cycle Progression via Its p55PIK Regulatory Subunit Interaction with PCNA
Guihua Wang,Xiaonian Cao,Senyan Lai,Xuelai Luo,Yongdong Feng,Xianmin Xia,Paul M. Yen,Jianping Gong,Junbo Hu +8 more
TL;DR: The results show that the p55PIK–PCNA interaction is important in regulating DNA synthesis and contributes to tumorigenesis, and provides a potential new target for anticancer drug development.
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