Xianlin Yang
Indiana University
7 Papers
28 Citations
Xianlin Yang is an academic researcher from Indiana University. The author has contributed to research in topics: Osteoclast & Progenitor cell. The author has an hindex of 6, co-authored 7 publications.
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Papers
In vivo demonstration that human parathyroid hormone 1-38 inhibits the expression of osteoprotegerin in bone with the kinetics of an immediate early gene.
J. E. Onyia,J. E. Onyia,R. R. Miles,Xianlin Yang,D. L. Halladay,J. Hale,A. Glasebrook,D. McClure,G. Seno,L. Churgay,S. Chandrasekhar,T. J. Martin,T. J. Martin +12 more
TL;DR: It is proposed that the rapid and transient decrease in OPG expression may initiate a cascade of events resulting in the differentiation of osteoclast progenitor as well as contribute to bone turnover.
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Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity
Yongzheng He,Karl Staser,Steven D. Rhodes,Yaling Liu,Xiaohua Wu,Su Jung Park,Jin Yuan,Xianlin Yang,Xiaohong Li,Li Jiang,Shi Chen,Feng Chun Yang +11 more
TL;DR: Examination of the consequence of Erk1 and Erk2 disruption in multiple functions of osteoclasts, specialized macrophage/monocyte lineage-derived cells that resorb bone showsErk1 positively regulates osteoclast development and bone resorptive activity, and rationale for the development of ErK1-specific inhibitors is provided.
Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model.
Wei Zhang,Steven D. Rhodes,Liming Zhao,Liming Zhao,Yongzheng He,Yingze Zhang,Yong Shen,Dalong Yang,Dalong Yang,Xiaohua Wu,Xiaohong Li,Xianlin Yang,Su Jung Park,Shi Chen,Charles H. Turner,Charles H. Turner,Feng Chun Yang +16 more
TL;DR: A novel murine NF1 model provides a platform to understand the cellular and molecular mechanisms underlying the pathogenesis of spinal deficits in NF1 patients, and demonstrates multiple structural and functional abnormalities in the lumbar vertebrae which recapitulate the dystrophic vertebral changes inNF1 patients.
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c-Fms Signaling Mediates Neurofibromatosis Type-1 Osteoclast Gain-In-Functions
Yongzheng He,Steven D. Rhodes,Shi Chen,Xiaohua Wu,Jin Yuan,Xianlin Yang,Li Jiang,Xianqi Li,Naoyuki Takahashi,Mingjiang Xu,Khalid S. Mohammad,Theresa A. Guise,Feng Chun Yang +12 more
TL;DR: It is found that PLX3397 prevented bone loss in Nf1+/−-OVX mice by reducing osteoclast differentiation and bone resorptive activity in vivo, implicate the M-CSF/c-Fms signaling axis as a critical pathway underlying the aberrant functioning of N f1 haploinsufficient osteoclasts and may provide a potential therapeutic target for treating NF1 associated osteoporosis and osteopenia.
Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation
Yi Zeng,Hal E. Broxmeyer,Karl Staser,Brahmananda R. Chitteti,Su Jung Park,Seongmin Hahn,Scott Cooper,Zejin Sun,Li Jiang,Xianlin Yang,Jin Yuan,Rachelle Kosoff,George E. Sandusky,Edward F. Srour,Jonathan Chernoff,D. Wade Clapp +15 more
TL;DR: Using a conditional Pak2 knockout mouse model, it is found that disruption of Pak2 in HSCs induced profound leukopenia and a mild macrocytic anemia, which may suggest underlying mechanisms by which Pak2 regulates granulocyte‐monocyte lineage commitment.