Xiangyang Jin
Children's Hospital Los Angeles
4 Papers
Xiangyang Jin is an academic researcher from Children's Hospital Los Angeles. The author has contributed to research in topics: Genetic enhancement & Severe combined immunodeficiency. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Xiangyang Jin include University of California, Los Angeles.
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Papers
β-globin gene transfer to human bone marrow for sickle cell disease
Zulema Romero,Fabrizia Urbinati,Sabine Geiger,Aaron R. Cooper,Jennifer Wherley,Michael L. Kaufman,Roger P. Hollis,Rafael Ruiz de Assin,Shantha Senadheera,Arineh Sahagian,Xiangyang Jin,Alyse Gellis,Xiaoyan Wang,David W. Gjertson,Satiro deOliveira,Pamela Kempert,Sally Shupien,Hisham Abdel-Azim,Mark C. Walters,Herbert J. Meiselman,Rosalinda B. Wenby,Theresa Gruber,Victor J. Marder,Thomas D. Coates,Donald B. Kohn +24 more
TL;DR: Results demonstrate that the CCL-βAS3-FB LV is capable of efficient transfer and consistent expression of an effective anti-sickling β-globin gene in human SCD BM CD34+ progenitor cells, improving physiologic parameters of the resulting red blood cells.
In Vivo Transduction by Intravenous Injection of a Lentiviral Vector Expressing Human ADA into Neonatal ADA Gene Knockout Mice: A Novel Form of Enzyme Replacement Therapy for ADA Deficiency
Denise A. Carbonaro,Denise A. Carbonaro,Xiangyang Jin,Denise Petersen,Xingchao Wang,Fred Dorey,Ki Soo Kil,Melissa B. Aldrich,Michael R. Blackburn,Rodney E. Kellems,Donald B. Kohn,Donald B. Kohn +11 more
TL;DR: The long-term expression of enzymatically active ADA achieved by this method, primarily from transduction of liver and lung, restored immunologic function and significantly extended survival.
Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion
Denise A. Carbonaro,Xiangyang Jin,Daniel Cotoi,Tiejuan Mi,Xiao Jin Yu,Dianne C. Skelton,Frederick Dorey,Rodney E. Kellems,Michael R. Blackburn,Donald B. Kohn,Donald B. Kohn +10 more
TL;DR: The absence of selective reconstitution by donor T lymphocytes in the ADA-deficient mice indicates that restoration of immune function occurred by rescue of endogenous ADA- deficient lymphocytes through cross-correction from the engrafted ADA-replete donor cells.
Preclinical Demonstration of Lentiviral Vector-mediated Correction of Immunological and Metabolic Abnormalities in Models of Adenosine Deaminase Deficiency
Denise A. Carbonaro,Lin Zhang,Xiangyang Jin,Claudia Montiel-Equihua,Sabine Geiger,Marlene Carmo,Aaron R. Cooper,Lynette D. Fairbanks,Michael L. Kaufman,Neil J. Sebire,Roger P. Hollis,Michael P. Blundell,Shantha Senadheera,Pei Yu Fu,Arineh Sahaghian,Rebecca Chan,Xiaoyan Wang,Kenneth Cornetta,Adrian J. Thrasher,Donald B. Kohn,H. Bobby Gaspar +20 more
TL;DR: In this article, a self-inactivating lentiviral vector (LV) with a codon-optimized human cADA gene under the control of the short form elongation factor-1α promoter (LV EFS ADA) was generated to improve the efficacy and safety of ADA-SCID gene therapy.