Xiangping Qian
GlaxoSmithKline
37 Papers
187 Citations
Xiangping Qian is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Myosin & Heart failure. The author has an hindex of 11, co-authored 36 publications.
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Papers
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Fady I. Malik,James J. Hartman,Kathleen A. Elias,Bradley P. Morgan,Hector P. Rodriguez,Katjuša Brejc,Robert L. Anderson,Sandra H. Sueoka,Kenneth Lee,Jeffrey T. Finer,Roman Sakowicz,Ramesh Baliga,David R. Cox,Marc Garard,Guillermo Godinez,Raja Kawas,Erica Kraynack,David Lenzi,Pu Ping Lu,Alexander Muci,Congrong Niu,Xiangping Qian,Daniel W. Pierce,Maria Pokrovskii,Ion Suehiro,Sheila Sylvester,Todd Tochimoto,Corey Valdez,Wenyue Wang,Tatsuo Katori,David A. Kass,You Tang Shen,Stephen F. Vatner,David J. Morgans +33 more
TL;DR: It is shown that omecamtiv mecarbil binds to the myosin catalytic domain and operates by an allosteric mechanism to increase the transition rate of myOSin into the strongly actin-bound force-generating state.
Patent
Certain amino-pyrimidines, compositions thereof, and methods for their use
Zhe Yang,Alex Muci,Jeffrey Warrington,Gustave Bergnes,Morgan Bradley P,Chuang Chihyuan,Romero Antonio,Scott Collibee,Xiangping Qian,Pu-Ping Lu +9 more
- 22 Apr 2011
TL;DR: In this article, a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmacologically acceptable salt thereof, is defined, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined as defined in this paper.
40
Patent
Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
Luke W. Ashcraft,Gustave Bergnes,Scott Collibee,Chihyuan Chuang,Jeff Gardina,Morgan Bradley P,Alex Muci,Xiangping Qian,Antonio Romero,Jeffrey Warrington,Zhe Yang +10 more
- 22 Apr 2011
TL;DR: In this paper, compounds of Formula I: Formula I or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.
33
Patent
Certain amino-pyridazines, compositions thereof, and methods of their use
Luke W. Ashcraft,Gustave Bergnes,Scott Collibee,Chihyuan Chuang,Jeff Gardina,Morgan Bradley P,Alex Muci,Xiangping Qian,Jeffrey Warrington,Zhe Yang,Pu-Ping Lu,Antonio Romero +11 more
- 22 Apr 2011
TL;DR: In this paper, a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmacologically acceptable salt thereof, is defined, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined as defined in this paper.
31
Patent
Compositions and methods for treating heart failure
Fady I. Malik,Adam Lewis Tomasi,Bainian Feng,Erica Kraynack,Kathleen A. Elias,Pu-Ping Lu,Whitney Walter Smith,Xiangping Qian,David J. Morgans +8 more
- 20 Dec 2002
TL;DR: In this article substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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