Xiangmei Zhou
China Agricultural University
136 Papers
339 Citations
Xiangmei Zhou is an academic researcher from China Agricultural University. The author has contributed to research in topics: Mycobacterium bovis & Microglia. The author has an hindex of 20, co-authored 127 publications.
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Papers
Antibody-Mediated Inhibition of Integrin α5β1 Blocks Neurotoxic Prion Peptide PrP106–126-Induced Activation of BV2 Microglia
Jiaxin Chang,Lifeng Yang,Mohammed Kouadir,Yun Peng,Siming Zhang,Fushan Shi,Xiangmei Zhou,Xiaomin Yin,Deming Zhao +8 more
TL;DR: The study unveils a previously unidentified role of α5β1 integrin as an intermediate signaling molecule in neurotoxic prion peptides–microglia interactions and identifies a potential molecular target for the modulation of prion-induced microglial activation.
Koumiss promotes Mycobacterium bovis infection by disturbing intestinal flora and inhibiting endoplasmic reticulum stress.
Haoran Wang,Tariq Hussain,Jiao Yao,Jing Li,Naveed Sabir,Yi Liao,Zhengmin Liang,Yuanzhi Wang,Yiduo Liu,Deming Zhao,Xiangmei Zhou +10 more
TL;DR: In this paper, the effect of koumiss on the gut microbiota and host immune response against M bovis infection was explored, and the authors found that the content of short-chain fatty acids was significantly lower in the khoumiss-treated group compared with the control group, while the expression of endoplasmic reticulum stress and apoptosis-related proteins in the lungs of the treated mice were significantly decreased.
Genomic analysis of diversity, biogeography, and drug resistance in Mycobacterium bovis.
Yuhui Dong,Yuqing Feng,Xichao Ou,Chunfa Liu,Weixing Fan,Yanlin Zhao,Yongfei Hu,Xiangmei Zhou +7 more
TL;DR: This study applies a bacterial genome-wide association study to capture associations between genomic variation and drug resistance in 74 newly isolated strains from China, and identifies genomic variations associated with an increased risk of resistance acquisition.
Generation of an inactivated vaccine for avian pathogenic Escherichia coli using microarrays: A more rational approach to inactivated vaccine design
Xiangmei Zhou,Philip J. Richards,Daniel Windhorst,Ariel Imre,Agnes Bukovinski,Jessica Ruggeri,Altayeb Elazomi,Paul A. Barrow +7 more
TL;DR: The approach of using gene expression to produce synthetic media for the generation of more effective bacterins could be used for a number of intracellular bacteria pathogens including Enteroinvasive E. coli, Salmonella, and the Pasteurella/Riemerella/Mannheimia group of organisms.
Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.
Syed Zahid Ali Shah,Syed Zahid Ali Shah,Deming Zhao,Giulio Taglialatela,Tariq Hussain,Haodi Dong,Naveed Sabir,Mazhar Hussain Mangi,Wei Wu,Mengyu Lai,Xixi Zhang,Yuhan Duan,Lu Wang,Xiangmei Zhou,Lifeng Yang +14 more
TL;DR: Results show that a therapeutic cocktail of FK506+minocycline is an attractive candidate for prolonged use in prion diseases and the authors encourage its further clinical development as a possible treatment for this disease.