Xiang Ye
Vanderbilt University
12 Papers
Xiang Ye is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
TL;DR: It is shown during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensing of mis Processed cellular RNAs.
Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.
Matthew Z. Madden,Xiang Ye,Channing Chi,Emilie L. Fisher,Melissa M. Wolf,Gabriel A. Needle,Jackie E. Bader,Andrew R. Patterson,Bradley I. Reinfeld,Madelyn D. Landis,Emma S. Hathaway,Richard T. O’Neil,John Karijolich,Mary Philip,Jeffrey C. Rathmell +14 more
TL;DR: This article showed that pan-glutamine inhibition with 6-diazo-5-oxo-l-norleucine (DON) and No-Q treatment can produce distinct metabolic differentiation trajectories in murine CD8 T cells.
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Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1
Saara Kaviany,Todd Bartkowiak,Daniel E. Dulek,Yasmin W. Khan,Madeline Hayes,Samuel Schaefer,Xiang Ye,Debolanle O. Dahunsi,James A. Connelly,Jonathan M. Irish,Jeffrey C. Rathmell +10 more
TL;DR: New features of STAT1 GOF patients are defined, including a differential hypersensitivity for IL-6 and a shared increase in markers of metabolism in many immune cell types that suggests a role for STAT1 in metabolic regulation of immunity.
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A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination
Naveenchandra Suryadevara,Amrendra Kumar,Xiang Ye,Meredith C. Rogers,John D. Williams,John T. Wilson,John Karijolich,Sebastian Joyce +7 more
TL;DR: In this article , the authors found that subunit vaccine-elicited lung interstitial CD8+ Trm cells were different from subunit vaccination-enhanced effector memory and splenic memory T cells, and that the transcriptome signature of sub-unit vaccine elicited T cells similar to those elicited by virus infection or vaccination.
PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity
Jackie E. Bader,Melissa M. Wolf,Matthew Z. Madden,Bradley I. Reinfeld,Emily N. Arner,Emma S. Hathaway,KayLee K. Steiner,Gabriel A. Needle,Madelyn D. Landis,Matthew A. Cottam,Xiang Ye,Anthos Christofides,Vassiliki A. Boussiotis,Scott M. Haake,Kathryn E. Beckermann,W. Kimryn Rathmell,Alyssa H. Hasty,Jeffrey C. Rathmell +17 more
TL;DR: This paper showed that metabolic signaling in obesity induces PD-1-mediated suppression of TAM function and reveal a unique macrophage-specific mechanism to modulate immune tumor surveillance and checkpoint blockade.
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