Xiang Ou
University of South China
10 Papers
114 Citations
Xiang Ou is an academic researcher from University of South China. The author has contributed to research in topics: Cholesterol & Liver X receptor. The author has an hindex of 8, co-authored 10 publications.
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Papers
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis.
TL;DR: In this article, the authors describe decades of research aimed at identifying key molecules and cellular players involved in each main aspect of hepatic cholesterol metabolism and summarize the recent advances regarding the biological processes of liver cholesterol transport and its role in NAFLD and atherosclerosis.
131
The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice.
Xiaoyan Dai,Xiang Ou,Xin-rui Hao,Dong-li Cao,Ya-Ling Tang,Yan-Wei Hu,Xiao-Xu Li,Chao-Ke Tang +7 more
TL;DR: Investigating the effect of a synthetic LXR agonist T0901317 on ATP-binding cassette transporter A1 (ABCA1) and NPC1 in apolipoprotein E knockout mice gives a new insight into the mechanism for antiatherogenic effect of LXR synthetic agonists.
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Effect of T0901317 on Hepatic Proinflammatory Gene Expression in ApoE−/− Mice Fed a High-fat/high-cholesterol Diet
TL;DR: The synthetic LXR agonist T0901317 has paradoxical roles in hepatic gene expression of proinflammatory cytokines in apolipoprotein E knockout mice fed an atherogenic diet.
24
Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells.
TL;DR: It is suggested that ISG15 reduces miR‐17‐5p levels and thereby promotes Beclin‐1‐mediated autophagy, resulting in increased cholesterol efflux from THP‐1 macrophage‐derived foam cells.
22
MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice
Qiong Ye,Guo-Ping Tian,Hai-Peng Cheng,Xin Zhang,Xiang Ou,Xiao-Hua Yu,Ru-Qi Tan,Feng-Yun Yang,Duo Gong,Chong Huang,Yan-Jun Pan,Jie Zhang,Ling-Yan Chen,Zhen-Wang Zhao,Wei Xie,Liang Li,Min Zhang,Xiao-Dan Xia,Xi-Long Zheng,Chao-Ke Tang +19 more
TL;DR: Using the well-characterized mouse atherosclerosis model of apolipoprotein E knockout, systemic delivery of miR-134 agomir markedly enhanced the atherosclerotic lesion size, together with a significant increase in proinflammatory cytokine secretion and peritoneal macrophages lipid contents.