Xiang Li
Pennsylvania State University
17 Papers
16 Citations
Xiang Li is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Xiang Li include West Virginia University & University of Pennsylvania.
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Papers
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX
TL;DR: The vLAMPS is a human, biomimetic liver MPS, in which the ECM and cell seeding of the intermediate layer prior to assembly, simplifies construction of the model and makes the platform user-friendly, and validated the computational modeling of zonation with oxygen sensitive and insensitive beads.
Microfabrication of cylindrical microfluidic channel networks for microvascular research
TL;DR: A reproducible, cost-effective, and flexible micromanufacturing process combined with photolithographic reflowable photoresist and soft lithography techniques to fabricate cylindrical microchannel and networks to address current limitations in the creation of engineered microvascular channels with complex three-dimensional geometries in the shape of microvessels.
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Selective stamp bonding of PDMS microfluidic devices to polymer substrates for biological applications
TL;DR: In this article, a PrimeCoat-Epoxy adhesive layer was used to form a permanent and leakage free bond between PDMS microfluidic devices and polymer substrates by selective stamp bonding.
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In vitro recapitulation of functional microvessels for the study of endothelial shear response, nitric oxide and [Ca2+]i.
TL;DR: An engineered microvessel model is presented that mimicked the dimensions and network structures of in vivo microvessels with a long-term and continuous perfusion capability, as well as high-resolution and real-time imaging capability and demonstrates a great potential for biological applications.
New insights into shear stress-induced endothelial signalling and barrier function: cell-free fluid versus blood flow.
TL;DR: Investigating how changes in blood flow altered EC signalling and endothelial function directly through wall SS and indirectly through SS effects on red blood cells (RBCs) found SS-dependent ATP release and SS-induced increases in EC [Ca2+]i and gap formation require the presence of RBCs.