Xian Yang
Lanzhou University
33 Papers
207 Citations
Xian Yang is an academic researcher from Lanzhou University. The author has contributed to research in topics: Neurotransmission & NMDA receptor. The author has an hindex of 12, co-authored 33 publications.
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Papers
Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn.
TL;DR: It was found that CFA did not affect the total protein level of NMDARs subunit NR1 in spinal dorsal horn, but NR1 immunoreactivity at synapses significantly increased after CFA injection, which was correlated with the development of mechanical allodynia.
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NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.
TL;DR: The data suggested that activation of spinal NMDARs was able to accumulate NR2BR at synapses via SFK signaling, which might exaggerate N MDAR‐dependent nociceptive transmission and contribute to NMDA‐induced nocICEptive behavioral hyperresponsiveness.
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GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
Jing Cao,Xian Yang,Yan-Ni Liu,Zhan-Wei Suo,Lei Shi,Cheng-Rong Zheng,Hongbin Yang,Shuai Li,Xiao-Dong Hu +8 more
TL;DR: Intathecal application of bicuculline to remove the inhibition of GABA(A) receptor antagonist readily elicited mechanical allodynia in naive mice, which could be dose-dependently attenuated by NMDARs antagonist D-APV, and suggested that removal of GABAergic inhibition allowed for PKA-mediated N MDARs phosphorylation and synaptic accumulation, thus exaggerating NMD ARs-dependent nociceptive transmission and behavioral sensitization.
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Activation of α2 adrenoceptors inhibited NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain.
TL;DR: Biochemical analysis in vivo revealed that intrathecal clonidine administration specifically decreased the content of GluN2B subunit-containing NMDAR at synaptosomal membrane fraction, a result associated closely with the alleviation of inflammatory pain.
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Fyn kinase-regulated NMDA receptor- and AMPA receptor-dependent pain sensitization in spinal dorsal horn of mice.
TL;DR: Inhibition of Src‐family protein tyrosine kinases in spinal dorsal horn has been established as an effective strategy for the alleviation of chronic pathological pain and whether Fyn is involved in spinal sensitization is far from being elucidated.
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