Xiali Yang
Chinese Academy of Sciences
8 Papers
Xiali Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Gene & Gene knockdown. The author has an hindex of 1, co-authored 2 publications.
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Papers
Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver
Bingbing He,Wenbo Peng,Wenbo Peng,Jia Huang,Hang Zhang,Yingsi Zhou,Xiali Yang,Jing Liu,Zhijie Li,Zhijie Li,Chunlong Xu,Mingxing Xue,Hui Yang,Pengyu Huang,Pengyu Huang +14 more
TL;DR: The present work supplies a successful proof-of-concept trial that suggests efficient and regulatory knockdown of target metabolic genes for a designed metabolism modulation in the liver in mouse hepatocytes.
Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver
Bingbing He,Wenbo Peng,Wenbo Peng,Jia Huang,Hang Zhang,Yingsi Zhou,Xiali Yang,Jing Liu,Zhijie Li,Zhijie Li,Chunlong Xu,Mingxing Xue,Hui Yang,Pengyu Huang,Pengyu Huang +14 more
TL;DR: The CasRx system was demonstrated to efficiently and functionally knock down genes related to metabolism functions, including Pten, Pcsk9 and lncLstr, in mouse hepatocytes, providing an effective strategy to reversibly modulate metabolic genes.
2
Research of the underwater vehicle technology in long-distance tunnels
Jifan Ouyang,Qixing Huang,Xiali Yang +2 more
- 18 Nov 2022
TL;DR: In this article , a solution of a long cable ROV underwater vehicle was proposed to detect underwater building anomalies in water diversion tunnels and water conservancy pipelines of hydropower plants.
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect
Huawei Tong,Jia Huang,Qingquan Xiao,Bin He,Xue Dong,Yuanhua Liu,Xiali Yang,Dingyi Han,Zikang Wang,Wenqin Ying,Runze Zhang,Yu Wei,Xuchen Wang,Chunlong Xu,Yingsi Zhou,Yanfei Li,Minqing Cai,Qifang Wang,Mingxing Xue,Guoling Li,Kailun Fang,Hainan Zhang,Huanming Yang +22 more
TL;DR: High-fidelity Cas13 variants exhibit minimal collateral effect for targeted RNA degradation in vivo.
In vivo treatment of tyrosinaemia with hypercompact Cas12f1
Ruochen Guo,Zhifang Li,Hainan Zhang,Chang Zhang,Xiaona Huo,Xiali Yang,Rongrong Yang,Yuanhua Liu,Xiaozhi Sun,Huanming Yang,Yingsi Zhou,Chunlong Xu +11 more
TL;DR: Taking advantage of its miniature size for in vivo delivery with an all-in-one single adeno-associated virus (AAV) vector, it is shown that Cas12f1 enabled in vivo editing in both mouse embryos and liver with minimal off-target effect.