14 Papers
16 Citations
Xia Wu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Hair cell & Autophagy. The author has an hindex of 7, co-authored 13 publications.
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Papers
The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.
Zuhong He,Sheng-yu Zou,Ming Li,Fu-ling Liao,Xia Wu,Haiying Sun,Xueyan Zhao,Yujuan Hu,Dan Li,Xiaoxiang Xu,Sen Chen,Yu Sun,Renjie Chai,Weijia Kong +13 more
TL;DR: FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways, and this study finds that cell death and apoptosis were significantly increased after LPS injury.
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FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway
Zuhong He,Zuhong He,Ming Li,Qiaojun Fang,Fu-ling Liao,Fu-ling Liao,Sheng-yu Zou,Xia Wu,Haiying Sun,Xueyan Zhao,Yujuan Hu,Xiao-Xiang Xu,Sen Chen,Yu Sun,Renjie Chai,Weijia Kong +15 more
TL;DR: In this article, the authors found that FOXG1 plays an important role in the auditory degeneration process through regulation of macroautophagy and autophagy activation, and that inhibition of FoxG1 decreased the autophagia activity and led to the accumulation of reactive oxygen species and subsequent apoptosis of cochlear hair cells.
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Reduced connexin26 in the mature cochlea increases susceptibility to noise-induced hearing lossin mice
Xing-Xing Zhou,Sen Chen,Le Xie,Yu-Zi Ji,Xia Wu,Wen-Wen Wang,Qi Yang,Jintao Yu,Yu Sun,Xi Lin,Weijia Kong +10 more
TL;DR: Data indicate that reduced Cx26 expression in the mature mouse cochlea may increase susceptibility to noise-induced hearing loss and facilitate the cell degeneration in the organ of Corti.
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Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the Gjb2 knockdown mouse model.
TL;DR: It is indicated that Gjb2 participates in postnatal development of the cytoskeleton in pillar cells during structural maturation of the organ of Corti, and this may lead to cochlear developmental abnormalities and deafness in the GJb2 knockdown mouse model.
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The spatial distribution pattern of Connexin26 expression in supporting cells and its role in outer hair cell survival
TL;DR: The results indicate that longitudinal Cx26-based channels are predominant in DCs during P3–P5, and this longitudinal KO pattern inDCs has a limited effect on DC survival or on its postnatal development.
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