52 Papers
497 Citations
Xi Wang is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 33 publications. Previous affiliations of Xi Wang include West Virginia University & University of Rochester.
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Papers
Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
Boris G. Wilson,Xi Wang,Xiaohua Shen,Elizabeth S. McKenna,Madeleine E. Lemieux,Yoon Jae Cho,Edward C. Koellhoffer,Scott L. Pomeroy,Stuart H. Orkin,Stuart H. Orkin,Charles W. M. Roberts +10 more
TL;DR: In this article, the authors investigated functional relationships between SNF5 and EZH2 in oncogenic transformation, and showed that inactivation of Ezh2 blocks tumor formation driven by Snf5 loss.
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•Journal Article
Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
TL;DR: It is demonstrated that although both cell lines contain equal levels of p53 mRNA, baseline protein levels are 4 times higher in WTK1, and hypothesize that this p53 mutation is responsible for the difference in apoptosis as well as for the differences in mutability and mutational spectra reported previously.
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Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.
Xi Wang,Courtney G. Sansam,Christopher S. Thom,Daniel Metzger,Julia A. Evans,Phuong L. Nguyen,Charles W. M. Roberts +6 more
TL;DR: These findings suggest that, much like the concept of oncogene addiction, targeted inhibition of SWI/SNF ATPase activity may be an effective therapeutic approach for aggressive SNF5-deficient human tumors.
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A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead.
TL;DR: The results suggest that the ALAD-2 genotype may influence the pharmacokinetic distribution and chronic renal toxicity of lead, perhaps due to differential binding of lead to the variant protein.
Wilms Tumor Gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using a tissue microarray.
Jakob Dupont,Xi Wang,David S. Marshall,Mario M. Leitao,Cyrus V. Hedvat,Amanda J. Hummer,Howard T. Thaler,Richard J. O'Reilly,Robert A. Soslow +8 more
TL;DR: WT1 was expressed in a wide variety of endometrial cancers and was most marked in malignant mixed Mullerian tumors (MMMTs), and there was a trend toward a worse clinical outcome for patients whose tumors expressed WT1.
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