Xi Jiang

TL;DR: Ligament reconstructions are performed in lineage tracing mice where α‐smooth muscle actin was used to label αSMA‐expressing progenitors within the bone marrow that produced zonal attachments, and the integration strength increased with time, requiring 112% greater force to remove the graft from the tunnel at 28 days compared with 14 days post‐surgery.

TL;DR: The results provide novel mechanistic details by which mechanical signals regulate tendon cell function to preserve matrix homeostasis through a Yap/Taz axis and demonstrate that genetic perturbation of a single protein can preserve cell and chromatin state following a loss of tension.

TL;DR: In this article , the authors define the spatiotemporal distribution and phenotypic profile of tendon resident macrophages and their crosstalk with neighboring tendon fibroblasts and the extracellular matrix (ECM) during murine tendon development, growth, and homeostasis.

TL;DR: In this paper, the authors used a novel cryohistology imaging platform, coupled with sequential multicolor fluorochrome injections, to demonstrate that MBF and remodeling-based bone formation have similar contributions to trabecular bone homeostasis.