Xanthe L Metcalf
3 Papers
Xanthe L Metcalf is an academic researcher. The author has contributed to research in topics: Chemistry & Cancer research. The author has co-authored 1 publications.
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Papers
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
Jessica L. Chitty,Michelle Yam,Lara Perryman,Amelia L. Parker,Joanna N. Skhinas,Yordanos F I Setargew,Ellie Mok,Emmi Tran,Rhiannon Grant,Sharissa L. Latham,Brooke A. Pereira,Shona Ritchie,Kendelle J. Murphy,Michael Trpceski,Alison D. Findlay,Pauline Melenec,Elysse C. Filipe,A. Nadalini,Sipiththa Velayuthar,Gretel Major,Kaitlin Wyllie,Michael Papanicolaou,Shivanjali Ratnaseelan,Phoebe A. Phillips,George Sharbeen,Janet Youkhana,Alice G. Russo,Antonia Blackwell,Jordan F. Hastings,Morghan C. Lucas,Cecilia R. Chambers,Daniel A Reed,Janett Stoehr,Claire Vennin,Ruth Pidsley,Anaiis Zaratzian,Andrew M. Da Silva,Michael Tayao,Bret Charlton,David Herrmann,Max Nobis,P. J. Clark,Andrew V. Biankin,Amber L. Johns,David R. Croucher,Adnan Nagrial,Anthony J. Gill,Sean M. Grimmond,Lorraine A. Chantrill,Angela Chou,Tanya Dwarte,Xanthe L Metcalf,G. Jeong,Lara Kenyon,Nicola Waddell,John V. Pearson,Ann-Marie Patch,Katia Nones,Felicity Newell,Pamela Mukhopadhyay,Venkateswar Addala,Stephen H. Kazakoff,Oliver Holmes,Conrad Leonard,Scott Wood,Oliver Hofmann,Jaswinder S. Samra,Nick Pavlakis,Jennifer Arena,H. High,Ray Asghari,Neil Merrett,Amitabha Das,P. Cosman,Kasim Ismail,A. Stoita,David B. Williams,Allan Spigellman,Duncan McLeo,Judy Kirk,James G. Kench,Peter Grimison,Charbel Sandroussi,Annabel Goodwin,R. S. Mead,Katherine L. Tucker,Lesley Andrews,M. Texler,Cindy Forrest,M. Ballal,D. Fletcher,M. V. Beilin,Kynan Feeney,K. Epari,Sanjay Mukhedkar,Nikolajs Zeps,Nan Q. Nguyen,Andrew Ruszkiewicz,C. Worthley,John Chen,Mark Brooke-Smith,V. Papangelis,Andrew D. Clouston,Andrew Barbour,T. J. O'Rourke,J. W. Fawcett,Kellee Slater,M. Hatzifotis,Peter Franklin Myra Hodgkinson,Mehrdad Nikfarjam,James R. Eshleman,Ralph H. Hruban,Christopher L. Wolfgang,Aldo Scarpa,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Nigel B. Jamieson,David K. Chang,Stephan Dreyer,Lea Abdulkhalek,T. Schmitz,Victoria Lee,Kym Pham Stewart,M. Arshi,Angela Steinmann,Marina Pajic,Paul Timpson,Wolfgang Jarolimek,Thomas R. Cox +129 more
TL;DR: PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor, is developed and validated and it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.
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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse
James R.W. Conway,Sean C. Warren,Young-Kyung Lee,Andrew T. McCulloch,Astrid Magenau,Victoria Lee,Xanthe L Metcalf,Janett Stoehr,Katharina Haigh,Lea Abdulkhalek,Cris S Guaman,Daniel A Reed,Kendelle J. Murphy,Brooke A. Pereira,Pauline Melenec,Cecilia R. Chambers,Sharissa L. Latham,Helen Lenthall,Elissa K. Deenick,Yuanqing Ma,Tri Giang Phan,Elgene Lim,Anthony M. Joshua,Stacey N. Walters,Shane T. Grey,Yan Shi,Lei Zhang,Herbert Herzog,David R. Croucher,Colinda L.G.J. Scheele,David Herrmann,Owen J. Sansom,Jennifer P. Morton,Antonella Papa,Jody J. Haigh,Max Nobis,Paul Timpson +36 more
TL;DR: In this paper , the Akt-FRET biosensor mouse was used to monitor spatial and temporal AKT activation in a live setting, allowing longitudinal assessment of AKT activity using intravital imaging in conjunction with image stabilization and optical window technology.
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Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis
Cecilia R. Chambers,Supitchaya Watakul,Peter Schofield,Anna E Howell,Jessie Zhu,Alice M H Tran,Nadia Kuepper,Daniel A Reed,Kendelle J. Murphy,Lily M Channon,Brooke A. Pereira,Victoria M Tyma,Victoria Lee,Michael Trpceski,Jake Henry,Pauline Melenec,Lea Abdulkhalek,Max Nobis,Xanthe L Metcalf,Shona Ritchie,Antonia L Cadell,Janett Stoehr,Astrid Magenau,Diego Chacon-Fajardo,Jessica L. Chitty,Savannah O'Connell,Anaiis Zaratzian,Michael Tayao,Ruth J Lyons,Leonard D Goldstein,Ashleigh Dale,Alexander Rookyard,Angela Connolly,Ben Crossett,Yen T H Tran,Peter Kaltzis,Claire Vennin,Marija Dinevska,David R. Croucher,Jaswinder S. Samra,Anubhav Mittal,Robert J Weatheritt,Andy Philp,Gonzalo del Monte-Nieto,Lei Zhang,Ronaldo F Enriquez,Thomas R. Cox,Mark Pinese,Nicola Waddell,Hao-Wen Sim,Tatyana Chtanova,Yingxiao Wang,Anthony M. Joshua,Lorraine Chantrill,Thomas R Jeffry Evans,Anthony J Gill,Jennifer P Morton,M. Pajic,Daniel Christ,Herbert Herzog,Paul Timpson,David Herrmann +61 more