Xander H.T. Wehrens
Baylor College of Medicine
301 Papers
1.3K Citations
Xander H.T. Wehrens is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Ryanodine receptor 2 & Ryanodine receptor. The author has an hindex of 69, co-authored 252 publications. Previous affiliations of Xander H.T. Wehrens include Boston Children's Hospital & Cardiovascular Institute Hospital.
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Papers
Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy
Ashish N. Rao,Hannah M. Campbell,Xiangnan Guan,Tarah A. Word,Xander H.T. Wehrens,Zheng Xia,Thomas A. Cooper +6 more
TL;DR: In this article, the authors developed a transgenic mouse model for tetracycline-inducible and heart-specific expression of human DMPK mRNA containing 960 CUG repeats.
Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy.
Yi-Chen Lai,Na Li,William Lawrence,Sufen Wang,Amber T. Levine,Daniela Burchhardt,Robia G. Pautler,Miguel Valderrábano,Xander H.T. Wehrens,Anne E. Anderson +9 more
- 23 Mar 2018
TL;DR: Using the pilocarpine‐induced acquired epilepsy model, altered myocardial ion channel levels and electrophysiological changes also occur in animals with long‐standing epilepsy.
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Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling.
Alejandra Cely-Ortiz,Juan Ignacio Felice,Leandro A. Diaz-Zegarra,Carlos Alfredo Valverde,Marilén Federico,Julieta Palomeque,Xander H.T. Wehrens,Evangelia G. Kranias,Ernesto A. Aiello,Elena C. Lascano,Jorge A. Negroni,Alicia Mattiazzi +11 more
TL;DR: The present work shows that SR Ca2+ load and RYR2 Ca 2+ sensitivity are major determinants of Ca2+.
Genome Editing and Cardiac Arrhythmias
TL;DR: In this article , the authors review progress in the field of cardiac genome editing, in particular, its potential utility in treating cardiac arrhythmias, and discuss genome editing methods by which DNA can be disrupted, inserted, deleted, or corrected in cardiomyocytes.
Chronic exercise: a contributing factor to atrial fibrillation?
TL;DR: There are only a limited number of studies to date that investigated the epidemiology of AF in athletes, and mechanisms underlying AF development in athletes are not well defined.
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