Xander H.T. Wehrens
Baylor College of Medicine
301 Papers
1.3K Citations
Xander H.T. Wehrens is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Ryanodine receptor 2 & Ryanodine receptor. The author has an hindex of 69, co-authored 252 publications. Previous affiliations of Xander H.T. Wehrens include Boston Children's Hospital & Cardiovascular Institute Hospital.
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Papers
Mechanisms underlying pathological Ca2+ handling in diseases of the heart
TL;DR: In this paper, the physiological regulation of Ca2+ handling and its role in maintaining normal cardiac rhythm and contractility is discussed, and the role of protein phosphatase subunits and striated muscle preferentially expressed protein kinase (SPEG) in atrial fibrillation, heart failure, and cardiomyopathies is highlighted.
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Cardiac‐specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure
Jimmonique Donelson,Qiongling Wang,Tanner O. Monroe,Xiqian Jiang,Jianjie Zhou,Han Yu,Qianxing Mo,Qin Sun,Juan C. Marini,Xinquan Wang,Paul A. Nakata,Kendal D. Hirschi,Jin Wang,George G. Rodney,Xander H.T. Wehrens,Ninghui Cheng +15 more
TL;DR: The findings demonstrate that Grx3 is an important factor in regulating cardiac hypertrophy and heart failure by modulating both cellular redox homeostasis and Ca2+ handling in the heart.
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Genetics of atrial fibrillation: an update.
TL;DR: A better understanding of how genes at or near these loci can affect the pathogenesis of atrial fibrillation may provide insight into novel therapeutic targets and ultimately lead to improved clinical care.
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Genetic inhibition of Nuclear Factor of Activated T-cell c2 (NFATc2) prevents atrial fibrillation in CREM transgenic mice.
Li Ni,Satadru K. Lahiri,Satadru K. Lahiri,Jiali Nie,Xiaolu Pan,Xiaolu Pan,Issam Abu-Taha,Julia O. Reynolds,Julia O. Reynolds,Hannah M. Campbell,Hannah M. Campbell,Haihao Wang,Markus Kamler,Wilhelm Schmitz,Frank U. Müller,Na Li,Na Li,Na Li,Xiang Wei,Dao Wen Wang,Dobromir Dobrev,Xander H.T. Wehrens +21 more
TL;DR: In this paper, the role of NFATc2 in the progression of atrial fibrillation was investigated in humans and mouse models, showing that activation of the nuclear factor of activated T-cell (NFAT) contributes to atrial remodeling.
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Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart.
David Y. Chiang,Satadru K. Lahiri,Guoliang Wang,Jason Karch,Meng C. Wang,Sung Y. Jung,Albert J. R. Heck,Arjen Scholten,Xander H.T. Wehrens +8 more
TL;DR: By applying state-of-the-art proteomic approaches, a number of novel RyR2 interactors in the mouse heart are discovered and specific alterations in the RyR1 interactome are defined that were dependent on the phosphorylation status of RyR 2 at S2814.
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