X Liu
University of Utah
12 Papers
25 Citations
X Liu is an academic researcher from University of Utah. The author has contributed to research in topics: Carotid body & Inflammation. The author has an hindex of 9, co-authored 10 publications.
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Papers
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body.
TL;DR: It is indicated that chemoreceptor adaptation involves novel neuroimmune mechanisms, which may alter the functional phenotypes of type I cells and chemoafferent neurons, and that CH induces IL-6 expression in supporting type II cells.
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Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body.
TL;DR: Data from concurrently exposing rats to hypobaric CH and bosentan are consistent with the hypothesis that CH-induced adaptation in the carotid body is at least partially mediated by signaling pathways involving ET receptors.
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The role of NADPH oxidase in carotid body arterial chemoreceptors.
Bruce Dinger,L. He,J. Chen,X Liu,Constancio Gonzalez,Ana Obeso,Karl Sanders,John R. Hoidal,Larry J. Stensaas,S.J. Fidone +9 more
TL;DR: O(2)-sensing in the carotid body occurs in neuroectoderm-derived type I glomus cells where hypoxia elicits a complex chemotransduction cascade involving membrane depolarization, Ca(2+) entry and the release of excitatory neurotransmitters.
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Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity
TL;DR: The findings indicate that chronic hypoxia induces inflammation-dependent phenotypic adjustments in chemoafferent neurons, and proton-gated channels appear to enhance chemoreceptor sensitivity.
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Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body
TL;DR: It is suggested that increased ROS production by NOX enzymes in type I cells dampens CH-induced hypersensitivity in carotid body chemoreceptors.
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