Wylie Vale
Salk Institute for Biological Studies
877 Papers
19.7K Citations
Wylie Vale is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 163, co-authored 876 publications. Previous affiliations of Wylie Vale include Texas Tech University Health Sciences Center & Hammersmith Hospital.
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Papers
Cyclic hexapeptides related to somatostatin. Synthesis and biological testing.
Christian Pattaroni,Pierluigi Lucietto,Murray Goodman,Gail Yamamoto,Wylie Vale,Luis Moroder,Lucia Gazerro,Walter Göhring,Bernhard Schmied,Erich Wünsch +9 more
TL;DR: A series of cyclic hexapeptide analogs related to somatostatin are reported, designed to examine the role of the so-called bridging region, Phe11-Pro6, which has been postulated to be important in maintaining the proper conformation of the biologically active tetrapeptide.
17
Effect of recombinant inhibin on follicle-stimulating hormone secretion by the female rat: interaction with a gonadotropin-releasing hormone antagonist and estrogen.
Catherine Rivier,Wylie Vale +1 more
TL;DR: The results indicate that plasma FSH levels in rats whose GnRH receptors or secretion are blocked can be further lowered by inhibin and the ability of rh-inhibin-A to interfere with FSH secretion in the ovariectomized rat appears to involve a mechanism independent of the GnRH drive.
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Effect of recombinant human inhibin on gonadotropin secretion by the male rat.
TL;DR: Results indicate that exposure of the male rat to inhibin for 6 h decreases FSH secretion, and that this effect is at least partially mediated through blunting of the pituitary response to GnRH, which appears to be of lesser importance in the intact male rat.
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Possible involvement of inhibin in altered follicle-stimulating hormone (FSH) secretion during dissociated luteinizing hormone (LH) and FSH release: unilateral castration and experimental cryptorchidism.
TL;DR: Male rats were either unilaterally or bilaterally castrated, or were rendered cryptorchid when they were either 15 or 45 days old and plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and immunoreactive inhibin-alpha (irI alpha) levels were measured by specific radioimmunoassays.