Wylie Vale

TL;DR: Biological activities of these analogues of luteinizing hormone releasing factor were determined in vitro, using LRF as the standard for the agonists and [des-His2,D-Ala6]-LRF for the antagonists.

TL;DR: It is demonstrated that CRFR2 gene transcription in the mature mouse is stimulated by both high-fat diet and chronic variable stress conditions, and the current findings further position the SMCRFR2 pathways as a relevant physiological system that may affect the known reciprocal relationship between psychological and physiological challenges and the metabolic syndrome.

TL;DR: Special emphasis is given to the TGF-β family of growth factors, in particular activin effects on the gonadotrope population, because a considerable body of evidence supports their contribution to the local modulation of the embryonic and postnatal pituitsary as well as pituitary pathogenesis.

TL;DR: A number of analogs have been synthesized that are at least as potent as CRF, and these analogs or pharmaceutically acceptable salts thereof can be administered to mammals to achieve a substantial elevation of ACTH, endorphin, β-lipotropin and corticosterone levels and/or a lowering of blood pressure over an extended period of time as mentioned in this paper.