Wylie Vale
Salk Institute for Biological Studies
877 Papers
19.7K Citations
Wylie Vale is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 163, co-authored 876 publications. Previous affiliations of Wylie Vale include Texas Tech University Health Sciences Center & Hammersmith Hospital.
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Papers
Corticotropin-releasing factor as a transmitter in the human olivocerebellar pathway
TL;DR: These findings in human brain, consistent with studies in tissues from rat, cat, and monkey, demonstrate that CRF may be a peptidergic transmitter in the IOC climbing fiber system and thatCRF receptors are expressed by cellular targets in the cerebellum.
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Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)
Dominic P. Behan,Ellen Potter,Kathy A. Lewis,Nancy A. Jenkins,Neal G. Copeland,Philip J. Lowry,Wylie Vale +6 more
TL;DR: The human CRF-binding protein gene has been cloned and mapped to the distal region of chromosome 13 and loci 5q in the mouse and human genomes, respectively.
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Glucocorticoids regulate the expression of the mouse urocortin II gene: A putative connection between the corticotropin-releasing factor receptor pathways
TL;DR: The results demonstrate that mUcn II mRNA expression is up-regulated by dexamethasone in a dose- and time-dependent fashion and propose a putative link between the CRF receptor 1 andCRF receptor 2 pathways.
Reproductive/endocrine and anaphylactoid properties of an LHRH-antagonist, ORF 18260 [Ac−DNAL1(2),4FDPhe2,D-Trp3,D-Arg6]−GnRH
TL;DR: It is demonstrated that continuous administration inhibits ovulation in rats, and ORF 18260 has contragestational activity in rats and hamsters but not in guinea pigs and mice, and it is suggested that cutaneous anaphylactoid-like reactions in rats are induced.
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Variable Tolerance of the Developing Follicle and Corpus Luteum to Gonadotropin-Releasing Hormone Antagonist-Induced Gonadotropin Withdrawal in the Human*
TL;DR: To examine the differential sensitivity of the ovary to temporary withdrawal of gonadotropin support at different stages of folliculogenesis and corpus luteum function, GnRH antagonist blockade of gonADotropin secretion was examined in 17 studies using the Nal-Glu Gn RH antagonist.
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