Wylie Vale
Salk Institute for Biological Studies
877 Papers
19.7K Citations
Wylie Vale is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 163, co-authored 876 publications. Previous affiliations of Wylie Vale include Texas Tech University Health Sciences Center & Hammersmith Hospital.
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Papers
New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro
Jean Rivier,John S. Porter,Catherine Rivier,Marilyn H. Perrin,Anne Z. Corrigan,William A. Hook,Reuben P. Siraganian,Wylie Vale +7 more
TL;DR: In order to minimize the adverse effect of histamine release in the rat of some gonadotropin releasing hormone (GnRH) antagonists, new structures with modifications at positions 1, 2, 3, 5, 6, 7, and 10 were synthesized and tested in several biological systems, causing a 100% inhibition of ovulation at 5 micrograms/kg or less.
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Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor
TL;DR: The data suggest that activin X1 receptor can serve as an activin type I receptor and that the diverse biological effects of activins may be mediated by a complex formed by the interaction of two transmembrane protein-serine kinases.
141
Ligand Requirements of the Human Corticotropin- Releasing Factor-Binding Protein*
Steve Sutton,Dominic P. Behan,S L Lahrichi,R. Kaiser,Anne Z. Corrigan,Philip J. Lowry,Ellen Potter,Marilyn H. Perrin,Jean Rivier,Wylie Vale +9 more
TL;DR: Testing the affinity of recombinant CRF-BP for synthetic analogs of CRF and peptides in the CRF family indicates that residues 9-28 are crucial for ligand binding, and suggests specific pharmacological inhibitors of the ligand-binding protein interaction might be used to therapeutically elevate free CRF levels.
140
Physiologic Testosterone Levels in Normal Men Suppress High-Density Lipoprotein Cholesterol Levels
TL;DR: The results imply that androgen levels in the normal adult male range have a suppressive effect on HDL cholesterol concentration and may contribute to the increased risk for coronary artery disease in men.
140
Age-dependent changes in physiological action, content, and immunostaining of inhibin in male rats.
TL;DR: It is suggested that endogenous inhibin plays a physiological role in suppressing FSH secretion in infantile male rats, at an age when Sertoli cells contain the largest amount of this protein.
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