Wylie Vale
Salk Institute for Biological Studies
877 Papers
19.7K Citations
Wylie Vale is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 163, co-authored 876 publications. Previous affiliations of Wylie Vale include Texas Tech University Health Sciences Center & Hammersmith Hospital.
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Papers
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.
Marilyn H. Perrin,Cynthia J. Donaldson,Ruoping Chen,Amy L. Blount,Travis Berggren,Louis Bilezikjian,Paul E. Sawchenko,Wylie Vale +7 more
TL;DR: Comparison of the amino acid sequences of CRF-RB and the previously cloned receptor reveals major differences in the N-terminal domain and in the extracellular loops, whereas the sequences of the intracellular loops are nearly identical.
D-Trp8-somatostatin: an analog of somatostatin more potent than the native molecule.
TL;DR: D-Trp8-somatostatin was synthesized by solid phase methodology and this tetradecapeptide was found to be 8 times more potent than somatstatin under different assay conditions.
Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.
Ellen Potter,D. P. Behan,D. P. Behan,Wolfgang H. Fischer,Elizabeth A. Linton,Philip J. Lowry,Wylie Vale +6 more
TL;DR: In this article, the authors reported the existence of a CRF-binding protein in human plasma which inactivates CRF and which has been proposed to prevent inappropriate pituitaryadrenal stimulation in pregnancy.
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists.
Jean Rivier,J. Gulyas,Dean A. Kirby,William Low,Marilyn H. Perrin,Koichi S. Kunitake,Michael R. DiGruccio,Joan Vaughan,Jean Claude Reubi,Beatrice Waser,Steven C. Koerber,V Martinez,Lei Wang,Yvette Taché,Wylie Vale +14 more
TL;DR: Evidence that members of the corticotropin releasing factor (CRF) family assume distinct structures when interacting with theCRF(1) and CRF(2) receptors is presented and deletions and substitutions known to increase duration of action are introduced to yield antagonists.
Immunohistological localization of growth hormone-releasing hormone in human tumors.
TL;DR: It can be concluded that GHRH may be found in a variety of tumors arising from and composed of peptide hormone-producing endocrine cells.