Wusheng Yan
University of Pennsylvania
10 Papers
261 Citations
Wusheng Yan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Epithelial sodium channel & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Wusheng Yan include Children's Hospital of Philadelphia.
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Papers
Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels
Samuel B. Goldfarb,Ossama B. Kashlan,Jeffrey N. Watkins,Laurence Suaud,Wusheng Yan,Thomas R. Kleyman,Ronald C. Rubenstein +6 more
TL;DR: Data are consistent with Hsc70 and Hsp70 having differential and antagonistic effects with regard to the intracellular trafficking of mENaC in oocytes, which may have an impact on the understanding and potential treatment of diseases of aberrant ion channel trafficking.
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Functional polymorphism in the carboxyl terminus of the α-subunit of the human epithelial sodium channel
Frederick F. Samaha,Ronald C. Rubenstein,Ronald C. Rubenstein,Wusheng Yan,M.C. Ramkumar,Daniel Levy,Yoon J. Ahn,Shaohu Sheng,Thomas R. Kleyman +8 more
TL;DR: It is suggested that hαT663A is a functional polymorphism that affects human ENaC surface expression that affects whole cell Na+ currents and surface expression.
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Differential modulation of a polymorphism in the COOH terminus of the α-subunit of the human epithelial sodium channel by protein kinase Cδ
TL;DR: The A663T polymorphism of the α-subunit of the human epithelial sodium channel (h ENaC) increases the functional and surface expression of αβγ-hENaC in Xenopus laevis oocytes.
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Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.
Laurence Suaud,Wusheng Yan,Marcelo D. Carattino,Amal Robay,Thomas R. Kleyman,Ronald C. Rubenstein +5 more
TL;DR: The data suggest that a structurally and functionally intact CFTR NBD-1 in activated CFTR can regulate mENaC surface expression independent of Cl(-) transport in Xenopus oocytes.
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Intracellular trafficking of a polymorphism in the COOH terminus of the α-subunit of the human epithelial sodium channel is modulated by casein kinase 1
TL;DR: The data suggest that additional residues outside of the alpha-h ENaC COOH terminus are important for modulation of alpha-T663-hENaC trafficking by CK1, and perhaps specifically CK1delta regulates the intracellular trafficking of thealpha-A663T functional polymorphism of hEN aC indirectly by altering the rate of alpha's biosynthesis and/or delivery to the plasma membrane.
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