Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized by a diversity of pharmacological effects. An extensive search in electronic databases (PubMed, Scopus, Ovid, Wiley, ProQuest, ISI, and Science Direct) were used to identify the pharmacological and clinical studies on Berberis vulgaris and berberine, during 2008 to 2015, using 'berberine' and 'Berberis vulgaris' as search words. We found more than 1200 new article studying the properties and clinical uses of berberine and B. vulgaris, for treating tumor, diabetes, cardiovascular disease, hyperlipidemia, inflammation, bacterial and viral infections, cerebral ischemia trauma, mental disease, Alzheimer disease, osteoporosis, and so on. In this article, we have updated the pharmacological effects of B. vulgaris and its active constituent, berberine. Copyright © 2016 John Wiley & Sons, Ltd.

Berberis Vulgaris and Berberine: An Update Review

Objective To observe the effect of berberine on pharmacokinetics of puerarin in rats. Methods Plasma puerarin concentration was determined by HPLC after intragastrical administration of puerarin(100 mg·kg-1) or puerarin combined with berberine(50,100,200mg·kg-1) in rats. The data were processed by DAS ver1.0 software to calculate the pharmacokinetic parameters. Results Chromatographic peaks for puerarin were separated well by the HPLC method. Regression analysis of the data of puerarin concentration against its peak area showed a good straight line in the range of 0. 10 ~ 10. 00 mg·L-1(r =0.999 5). The main pharmacokinetic parameters of puerarin before and after coadministration of berberine were as follows:Cmaxwere(0. 54 ± 0. 05),(0. 59 ± 0. 03),(0.67 ±0.02),(0.73 ±0.03)mg·L-1;AUC0 ~ ∞were(4. 90 ± 2. 91),(4. 63 ± 2. 11),(3. 42 ± 2. 44),(6. 18 ± 2. 57) mg·L-1·h-1;CL were(26.92 ±16.24),(25.94 ±13.36),(44.58 ±30.36),(18.82 ±8.47)L·h-1·kg-1. Conclusions High dose of berberine can significantly enhance puerarin absorption in rats.

Effect of berberine on pharmacokinetics of puerarin in rats

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Effect of berberine on pharmacokinetics of puerarin in rats