Wu Hao
Keio University
13 Papers
89 Citations
Wu Hao is an academic researcher from Keio University. The author has contributed to research in topics: Osteoclast & Biology. The author has an hindex of 12, co-authored 12 publications.
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Papers
The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis
Yoshiteru Miyauchi,Ken Ninomiya,Hiroya Miyamoto,Akemi Sakamoto,Ryotaro Iwasaki,Hiroko Hoshi,Kana Miyamoto,Wu Hao,Shigeyuki Yoshida,Hideo Morioka,Kazuhiro Chiba,Shigeaki Kato,Takeshi Tokuhisa,Mitinori Saitou,Yoshiaki Toyama,Toshio Suda,Takeshi Miyamoto +16 more
TL;DR: A Blimp1–Bcl6–osteoclastic molecule axis is revealed, which critically regulates bone homeostasis by controlling osteoclastogenesis and may provide a molecular basis for novel therapeutic strategies.
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HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis
Yoshiteru Miyauchi,Yuiko Sato,Tami Kobayashi,Shigeyuki Yoshida,Tomoaki Mori,Hiroya Kanagawa,Eri Katsuyama,Atsuhiro Fujie,Wu Hao,Kana Miyamoto,Toshimi Tando,Hideo Morioka,Morio Matsumoto,Pierre Chambon,Randall S. Johnson,Shigeaki Kato,Yoshiaki Toyama,Takeshi Miyamoto +17 more
TL;DR: In bone-resorbing osteoclasts, estrogen-dependent destabilization of hypoxia-inducible factor 1 alpha (HIF1α), which is unstable in the presence of oxygen, plays a pivotal role in promoting bone loss in estrogen-deficient conditions.
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Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization
Kana Miyamoto,Shigeyuki Yoshida,Miyuri Kawasumi,Kazuaki Hashimoto,Tokuhiro Kimura,Yuiko Sato,Tami Kobayashi,Yoshiteru Miyauchi,Hiroko Hoshi,Ryotaro Iwasaki,Hiroya Miyamoto,Wu Hao,Hideo Morioka,Kazuhiro Chiba,Takashi Kobayashi,Hisataka Yasuda,Josef M. Penninger,Yoshiaki Toyama,Toshio Suda,Takeshi Miyamoto +19 more
TL;DR: The mobilization of hematopoietic stem cells does not require osteoclasts, which may even have an inhibitory effect.
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TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.
Tomoaki Mori,Yuiko Sato,Kana Miyamoto,Tami Kobayashi,Takatsune Shimizu,Hiroya Kanagawa,Eri Katsuyama,Atsuhiro Fujie,Wu Hao,Toshimi Tando,Ryotaro Iwasaki,Hiromasa Kawana,Hideo Morioka,Morio Matsumoto,Hideyuki Saya,Yoshiaki Toyama,Takeshi Miyamoto +16 more
TL;DR: Inflammatory cytokines are required to promote tumorigenesis even in mutation-induced tumors, and TNFα/IL-1 and ERK may represent therapeutic targets for osteosarcoma.
Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy
Toshimi Tando,Akiyoshi Hirayama,Mitsuru Furukawa,Yuiko Sato,Tami Kobayashi,Atsushi Funayama,Arihiko Kanaji,Wu Hao,Ryuichi Watanabe,Mayu Morita,Takatsugu Oike,Kana Miyamoto,Tomoyoshi Soga,Masatoshi Nomura,Akihiko Yoshimura,Masaru Tomita,Morio Matsumoto,Masaya Nakamura,Yoshiaki Toyama,Takeshi Miyamoto +19 more
TL;DR: It is shown that skeletal muscle immobilization elevates Smad2/3 protein but not mRNA levels in muscle, promoting atrophy, and myostatin, which negatively regulates muscle hypertrophy, is dispensable for denervation-induced muscle atrophy and Smad 2/3protein accumulation.
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