Synthesis, structures and Helicobacter pylori urease inhibitory activity of copper(II) complexes with tridentate aroylhydrazone ligands.

Synthesis, structures and urease inhibitory activity of cobalt(III) complexes with Schiff bases.

Nine new copper(II) complexes derived from various Schiff bases were prepared. They are [Cu2Br2(L1)2] (1), [Cu(L2)2]·2NO3·2CH3OH (2), [Cu(L3)2]·2Br (3), [Cu(L4)2] (4), [Cu2Cl4(L2)2] (5), [Cu2Cl2(L5)2] (6), [CuL6(NCS)] (7), [CuClL6]·CH3OH (8), and [Cu2(L7)2] (9), where L1 is the monoanionic form of 2-chloro-N′-(4-diethylamino-2-hydroxybenzylidene)benzohydrazide (HL1), L2 is the zwitterionic form of 4-methyl-2-((3-morpholinopropylimino)methyl)phenol (L2), L3 is the zwitterionic form of 2-bromo-4-chloro-6-((2-(2-hydroxyethylamino)ethylimino)methyl)phenol (L3), L4 is the monoanionic form of 2-bromo-4-chloro-6-((cyclopentylimino)methyl)phenol (HL4), L5 is the monoanionic form of 2-((cyclopropylimino)methyl)-4-methylphenol (HL5), L6 is the monoanionic form of 4-methyl-2-((pyridin-2-ylmethylimino)methyl)phenol (HL6), and L7 is the dianionic form of N,N′-bis(5-methylsalicylidene)-1,4-diiminobutane (H2L7). The complexes were characterized by infrared and UV-Vis spectra, and single crystal X-ray diffraction. The Cu atoms in complex 1 display square pyramidal coordination, in complex 5 display trigonal bipyramidal coordination, in complex 9 show tetrahedrally distorted square planar coordination, and in the remaining complexes display square planar coordination. Complexes 2, 3, 5, 7 and 8 show effective urease inhibitory activities, with IC50 values of 0.37 ± 1.22, 0.21 ± 0.97, 0.03 ± 0.78, 0.39 ± 0.58 and 0.76 ± 0.95 μM, respectively. Molecular docking study of the complexes with Helicobacter pylori urease was performed. Complex 5 has the most effective activity against urease, with a mixed competitive inhibition mechanism. The complex interacts with the nickel atom of the urease active center, and with the remaining parts of the complex molecule block the entrance of the urease active pocket.

Inhibition studies of Helicobacter pylori urease with Schiff base copper(II) complexes

Pd(II) and Ni(II) complexes containing an asymmetric Schiff base ligand: Synthesis, x-ray crystal structure, spectroscopic investigations and computational studies

Background and the purpose of the study: Helicobacter pylori (H. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation depends upon multi-drug therapy. The most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or synthetic anti-H. pylori agents.
Methods: In this report 21 randomly selected herbal methanolic extracts were evaluated for their effect on inhibition of Jack-bean urease using the indophenol method as described by Weatherburn. The inhibition potency was measured by UV spectroscopy technique at 630 nm which attributes to released ammonium.
Results: Among these extracts, five showed potent inhibitory activities with IC50 ranges of 18-35 µg/mL. These plants are Matricaria disciforme (IC50=35 µg/mL), Nasturtium officinal (IC50=18 µg/mL), Punica granatum (IC50=30 µg/mL), Camelia sinensis (IC50=35 µg/mL), Citrus aurantifolia (IC50=28 µg/mL).
Conclusion: Medicinal plants, traditional medicinal and other natural sources are still good source for lead discovery. The results of this study revealed that random screening of medicinal plants could lead to introducing new candidate for further studies which, in the end, can help and enhance human health.

A Preliminary Investigation of the Jack-Bean Urease Inhibition by Randomly Selected Traditionally Used Herbal Medicine

Synthesis, structures and urease inhibition studies of dimeric copper(II) complexes of Schiff bases derived from glycine

Two new salen copper(II) and nickel(II) complexes, Cu(salen) (1) and Ni(salen) (2), where salen = cis-(N,N′-bis(5-chlorosalicylidene)cyclohexane-1,2-di-amine, were synthesized and structurally characterized The solid state structures of both complexes 1 and 2 present the slightly distorted square-planar MN2O2 chromophore The Cu···Cu distance in complex 1 is 6054 A, while the Ni···Ni distance in complex 2 is 3448 A The experimental studies were complemented by theoretical calculations

Synthesis and Solid State Structures of Schiff Base Copper (II) and Nickel(II) Complexes Derived From cis-1,2-diaminocyclohexane

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Wu Chen

Author Tools

Chat about Author

Papers

Synthesis, structures and urease inhibition studies of dimeric copper(II) complexes of Schiff bases derived from glycine

Synthesis and Solid State Structures of Schiff Base Copper (II) and Nickel(II) Complexes Derived From cis-1,2-diaminocyclohexane