Wouter N. Leonhard
Leiden University Medical Center
33 Papers
138 Citations
Wouter N. Leonhard is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Autosomal dominant polycystic kidney disease & Polycystic kidney disease. The author has an hindex of 20, co-authored 30 publications. Previous affiliations of Wouter N. Leonhard include Leiden University.
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Papers
Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease.
Irma S. Lantinga-van Leeuwen,J. G. Dauwerse,Hans J. Baelde,Wouter N. Leonhard,Annemieke van de Wal,Christopher J. Ward,Sjef Verbeek,Marco C. DeRuiter,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +10 more
TL;DR: It is proposed that in patients reduced PKD1 expression of the normal allele below a critical level, due to genetic, environmental or stochastic factors, may lead to cyst formation in the kidneys and other clinical features of ADPKD.
Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways
Hester Happé,Wouter N. Leonhard,Annemieke van der Wal,Bob van de Water,Irma S. Lantinga-van Leeuwen,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +7 more
TL;DR: It is proposed that during tissue repair, the integrity of the newly formed Pkd1-deficient cells is modified rendering them susceptible to subsequent cyst formation, and Aberrant planar cell polarity (PCP) signaling and increased canonical Wnt signaling are suggested to be involved in Cyst formation.
Altered Hippo signalling in polycystic kidney disease.
Hester Happé,Annemieke van der Wal,Wouter N. Leonhard,Steven J. Kunnen,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +6 more
TL;DR: Altered activity of the Hippo pathway was confirmed in renal tissues from human ADPKD and ARPKD patients, as well as in cystic renal tumours, strengthening the concept that during epithelial repair Four‐jointed is involved in PCP signalling, while in cysts kidneys it is related to Hippo signalling and cyst growth.
122
Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Sabrine Hassane,Wouter N. Leonhard,Annemieke van der Wal,Lukas J. A. C. Hawinkels,Irma S Lantinga-van Leeuwen,Peter ten Dijke,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +8 more
TL;DR: The results exclude TGFβ signalling at the initiation of cystogenesis, but indicate an important role during cyst progression and in fibrogenesis of progressive ADPKD.
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Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells
Martijn S. Scheffers,Hang Le,Paola van der Bent,Wouter N. Leonhard,Frans A. Prins,Lia Spruit,Martijn H. Breuning,Emile de Heer,Dorien J.M. Peters +8 more
TL;DR: The data suggest that polycystin-2 can move freely in certain regions of the membrane where it probably functions as a channel, activated by, or in complex with, polycyStin-1.