Wouter Laroy
Ghent University
24 Papers
266 Citations
Wouter Laroy is an academic researcher from Ghent University. The author has contributed to research in topics: Glycomics & Tropomyosin receptor kinase A. The author has an hindex of 14, co-authored 24 publications. Previous affiliations of Wouter Laroy include Flanders Institute for Biotechnology.
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Papers
Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics
Nico Callewaert,Nico Callewaert,Hans Van Vlierberghe,Annelies Van Hecke,Wouter Laroy,Joris R. Delanghe,Roland Contreras +6 more
TL;DR: The 'clinical glycomics' technology, based on DNA sequencer/fragment analyzers, yielded a biomarker that distinguished compensated cirrhotic from noncirrhotic chronic liver disease patients, with 79% sensitivity and 86% specificity, which could obviate biopsy in many cirrhosis patients.
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N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus.
Xue-En Liu,Xue-En Liu,Xue-En Liu,Liesbeth Desmyter,Liesbeth Desmyter,Chunfang Gao,Wouter Laroy,Wouter Laroy,Sylviane Dewaele,Sylviane Dewaele,Valerie Vanhooren,Valerie Vanhooren,Ling Wang,Hui Zhuang,Nico Callewaert,Nico Callewaert,Claude Libert,Claude Libert,Roland Contreras,Roland Contreras,Cuiying Chen,Cuiying Chen +21 more
TL;DR: In this paper, the use of blood serum N-glycan fingerprinting as a tool for the diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis induced by hepatitis B virus (HBV) was evaluated.
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N-Glycan profiling in the study of human aging
TL;DR: This work describes a detailed protocol for the analysis of N-linked glycans in blood via DNA sequencing equipment-Fluorophore Ass Carbohydrate Electrophoresis (DSA-FACE), and reports that N-glycan profiling of the human serum shows substantial changes with increasing age.
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Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase.
Alicja Woronowicz,Schammim Ray Amith,Kristof De Vusser,Wouter Laroy,Roland Contreras,Sameh Basta,Myron R. Szewczuk +6 more
TL;DR: A membrane sialidase-controlling mechanism that depends on ligand binding to its receptor to induce enzyme activity which targets and desialylates the receptor and, consequently, causes the induction of receptor dimerization and activation is discovered.
Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis
K. Van Beneden,Ken Coppieters,Wouter Laroy,F De Keyser,Ilse Hoffman,F. Van den Bosch,B. Vander Cruyssen,Michael B. Drennan,Peggy Jacques,Pieter Rottiers,G. Verbruggen,Roland Contreras,Nico Callewaert,Dirk Elewaut +13 more
TL;DR: Improved DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis technology demonstrates that the UGS of serum immunoglobulins changes during the disease course of CIA and that this UGS is inhibited by antigen-specific and antigen-independent treatment procedures.
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