Won Yong Lee
University of Utah
22 Papers
84 Citations
Won Yong Lee is an academic researcher from University of Utah. The author has contributed to research in topics: Gating & Ion channel. The author has an hindex of 11, co-authored 22 publications. Previous affiliations of Won Yong Lee include Mayo Clinic.
Chat about Author
Papers
A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors
Craig S. Walker,Stori Jensen,Michael Ellison,Jose A. Matta,Won Yong Lee,Julita S. Imperial,Nick Duclos,Penelope J. Brockie,David M. Madsen,John T.R. Isaac,Baldomero M. Olivera,Andres V. Maricq +11 more
TL;DR: The identification and characterization of a novel polypeptide from the venom of a predatory marine snail Conus striatus that specifically disrupts the desensitization of AMPA receptors (AMPARs) are reported, providing insight into the mechanisms that regulate receptor desensitized state and revealing the fundamental importance of desensItization for regulating neural function.
75
Nicotinic Receptor Interloop Proline Anchors β1-β2 and Cys loops in Coupling Agonist Binding to Channel Gating
TL;DR: It is found that in contributing to channel gating, αVal 46 and αVal 132 of the signature Cys loop couple energetically to αPro 272, suggesting naturally occurring substitutions at these positions enable a diverse range of gating rate constants among the Cys-loop receptor superfamily.
52
Mechanistic diversity underlying fast channel congenital myasthenic syndromes.
TL;DR: A host of missense mutations in muscle nicotinic receptor subunits have been identified as the cause of congenital myasthenic syndromes (CMS), and a review focuses on new mechanisms underlying the FCCMS.
14
A synthetic glycosaminoglycan reduces sinonasal inflammation in a murine model of chronic rhinosinusitis
Jeremiah A. Alt,Won Yong Lee,Brock M Davis,Justin R. Savage,Thomas P. Kennedy,Glenn D. Prestwich,Abigail Pulsipher +6 more
TL;DR: The data suggest that GM-1111 significantly reduces local and systemic effects of CRS-associated sinonasal inflammation, as well as innate immunity- and adaptive immunity-associated cytokine gene expression.
•Journal Article
Behavioral changes with alterations of choline acetyltransferase immunoreactivities induced by N-butyl benzenesulfonamide.
TL;DR: N-butyl benzenesulfonamide (NBBS), one of the sulfonamide plasticizers, induced characteristic effects to Wistar rats after acute repeated exposures that showed pica, staggering gait with hindlimb-paresis and splaying, teeth-grinding, self paw-biting and coma.
10